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CXCR2 gene

Known as: CMKAR2, C-X-C motif chemokine receptor 2, IL8RB 
This gene is involved in pro-inflammatory cytokine cellular responses, neutrophil activation, and chemotaxis.
National Institutes of Health

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C-X-C Chemokine Receptor Type 2, humanChemotaxisCytokine Signaling ProcessG Protein-Coupled Receptor Signaling

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IL8RB wt Allele

Papers overview

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2018
2018
Abstract LB-064: The discovery of novel small molecular CXCR2 antagonist by using ligand-based pharmacophore model
Tumor metastasis has become a fatal disease progress which greatly influence cancer treatment and prognosis. Generally, the… 
2017
2017
Corrigendum: CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses
Scientific Reports 7: Article number: 42681; published online: 16 February 2017; updated: 10 April 2017. The original version of… 
2014
2014
CXCL 7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C , VEGF-D in Human Breast Cancer Cells
Increased expression of lymphangiogenesis factors VEGF-C/D and heparanase has been correlated with the invasion of cancer… 
2013
2013
Evidence of Elevated CXCR2 Agonists in Stable Outpatients with CysticFibrosis Compared with Healthy Controls
Introduction: Recruitment and activation of inflammatory cells contributes to the pathophysiology of Cystic Fibrosis (CF… 
2013
2013
Cancer Therapeutics Insights Targeting CXCR 2 Enhances Chemotherapeutic Response , Inhibits Mammary Tumor Growth , Angiogenesis , and Lung Metastasis
Breast cancer is one of the leading causes of cancer deaths among females. Many challenges exist in the currentmanagement of… 
2013
2013
Abstract 548: CXCR2 controls breast cancer metastasis and chemoresistance through PI3K/AKT and COX-2 signalings.
Background: Breast cancer is the chief culprit leading to woman9s death. The major cause is the chemoresistance and distant… 
2012
2012
A potential role of the GRO-α/CXCR2 system in Sjögren’s syndrome: regulatory effects of pro-inflammatory cytokines
Chemokines, small pro-inflammatory cytokines, are involved in migration of inflammatory cells in inflamed tissues and recent… 
2011
2011
Растворимая форма рецептора интерлейкина-8 CXCR2 в качестве маркера вовлечения нейтрофильных лейкоцитов крови человека в локальный воспалительный процесс
The decreased level of the chemotactical receptor CXCR2 expression is accompanied by the emergence of soluble CXCR2 (рCXCR2) in… 
2011
2011
Roles of mechanical force and CXCR1/CXCR2 in shear-stress-induced endothelial cell migration
We previously demonstrated that CXCR1 and CXCR2 are novel mechanosensors mediating laminar shear-stress-induced endothelial cell… 
2008
2008
The chemokine receptors XCR1, CXCR1 and CXCR2 regulate oral epithelial cell behaviour
Chemokines are chemoattractant cytokines which act on specific receptors and play an important role in tumour biology. The aim of…