• Publications
  • Influence
Genome-wide analysis of mammalian promoter architecture and evolution
TLDR
These tagging methods allow quantitative analysis of promoter usage in different tissues and show that differentially regulated alternative TSSs are a common feature in protein-coding genes and commonly generate alternative N termini.
The Transcriptional Landscape of the Mammalian Genome
TLDR
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Molecular cloning of a potential proteinase activated receptor.
TLDR
This, to the authors' knowledge, is the second example, besides the thrombin receptor, of a proteolytically activated seven-transmembrane G-protein-coupled receptor, and is provisionally named proteinase activated receptor 2.
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
TLDR
It is reported that a long noncoding RNA is directly implicated in the increased abundance of Aβ 1–42 in Alzheimer's disease.
Antisense Transcription in the Mammalian Transcriptome
TLDR
Experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs is presented, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals.
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
TLDR
The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics.
Striatal microRNA controls cocaine intake through CREB signaling
TLDR
It is reported that microRNA-212 (miR-212) is upregulated in the dorsal striatum of rats with a history of extended access to cocaine, revealing new molecular regulators that control the complex actions of cocaine in brain reward circuitries and providing an entirely new direction for the development of anti-addiction therapeutics based on the modulation of noncoding RNAs.
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
TLDR
The data suggest that pharmacological approaches targeting NATs can confer locus-specific gene upregulation effects and that inhibition of NATs leads to increases in glial-derived neurotrophic factor (GDNF) and ephrin receptor B2 (EPHB2) mRNA.
Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: Distinct distribution from GALR1
TLDR
The findings indicate that dorsal root ganglia express by far the highest levels of GALR2 mRNA in the rat central nervous system (CNS), suggesting that specific physiologic effects of galanin may be ascribed to the G ALR2 galan in receptor subtype.
Regulatory roles of natural antisense transcripts
TLDR
Functional validation studies indicate that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.
...
...