A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells
@article{Jazin1993APB, title={A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells}, author={Elena E. Jazin and H. Yoo and Anders Blomqvist and Frances Yee and Gezhi Weng and Mary W. Walker and John A. Salon and Dan Larhammar and Claes Wahlestedt}, journal={Regulatory Peptides}, year={1993}, volume={47}, pages={247-258} }
89 Citations
Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig.
- BiologyGenome research
- 2000
The sequence comparisons suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) represents the ancestral configuration, whereas the porcine cluster has been split by two inversions on SSC8.
Multiplicity of neuropeptide Y receptors: cloning of a third distinct subtype in the zebrafish.
- BiologyBiochemical and biophysical research communications
- 1997
This work suggests that NPY has more receptor subtypes than any other peptide that binds to G protein-coupled receptors, and work is in progress to see if the zebrafish receptors are present in mammals.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.
- BiologyComparative biochemistry and physiology. Part B, Biochemistry & molecular biology
- 2011
Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide
- BiologyRegulatory Peptides
- 1996
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig
- BiologyBritish journal of pharmacology
- 2002
It is shown that NPY stimulates feeding in guinea‐pigs through Y1 and Y5 receptors, which suggests that either Y1 or Y4 receptors or both may mediate NPY induced hyperphagia also in other orders of mammals.
Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevis.
- BiologyBiochimica et biophysica acta
- 1995
Neuropeptide Y‐family receptors Y6 and Y7 in chicken
- BiologyThe FEBS journal
- 2006
The phylogenetic and chromosomal analyses support the ancient origin of these Y receptor genes by chromosome duplications in an early (pregnathostome) vertebrate ancestor.
Development of binding and functional assays for the neuropeptide Y Y 2 and Y 4 receptors
- Biology, Chemistry
- 2006
The main advantage of the established aequorin assay is the automation of the injection and recording process, and it is possible to perform more than 400 single calcium assays per day compared to about 40 assays performed with the spectrofluorimetric or flow cytometric calcium assay.
References
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Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.
- BiologyThe Journal of biological chemistry
- 1992
Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY.
- Biology, ChemistryLife sciences
- 1992
Sequence and expression of a neuropeptide Y receptor cDNA.
- Biology, ChemistryMolecular pharmacology
- 1991
The polymerase chain reaction was used to isolate novel GTP-binding protein (G protein)-coupled receptors from bovine locus coeruleus (LC), a brain region enriched in the neuropeptide Y (NPY) system,…
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1992
The cloning, functional expression, and tissue distribution of two different somatostatin receptors (SSTRs) are reported, showing that SSTR1 and SSTR2 are expressed at highest levels in jejunum and stomach and in cerebrum and kidney, respectively.
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.
- BiologyBiochemistry
- 1990
Two variants of the human N-formylpeptide chemoattractant receptor have been isolated from a CDM8 expression library prepared from mRNA of human myeloid HL-60 cells differentiated to the granulocyte phenotype with Bt2cAMP, and sequence comparison established that the fMLP receptor belongs to the G-protein-coupled receptor superfamily.
Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes
- Biology, ChemistryPeptides
- 1990
Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster.
- BiologyThe Journal of biological chemistry
- 1992
Neuropeptide Y Receptor Subtypes, Y1 and Y2
- BiologyAnnals of the New York Academy of Sciences
- 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, and work has indicated that the Y2-receptor may occur postjunctionally in selected sympathetic effector systems.
Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?
- BiologyAnnual review of pharmacology and toxicology
- 1993
It has been appreciated that NPY may also be an important messenger in its own right , perhaps particularly in the brain, where NP Y has been frequently used to study cotransmission, particularly in its relation to the "classical" neurotransmitter norepinephrine.
125I-neuropeptide Y and 125I-peptide YY bind to multiple receptor sites in rat brain.
- Biology, ChemistryMolecular pharmacology
- 1988
It is proposed that rat brain contains a minor population of high affinity NPY binding sites with an intermediate dissociation rate and no sensitivity to Gpp(NH)p, a nonhydrolyzable analog of GTP.