Rab GTPases in Endocytosis Pathway
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ABSTRACT Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a… Expand Summary The Rab GTPases recruit peripheral membrane proteins to intracellular organelles. These Rab effectors typically mediate… Expand Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that can replicate within infected macrophages. The ability of M… Expand BACKGROUND
Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are… Expand ABSTRACT Chlamydiae are intracellular bacteria that develop within a membrane-bound vacuole called an inclusion. To ensure that… Expand Rab GTPases regulate membrane trafficking by cycling between inactive (GDP-bound) and active (GTP-bound) conformations. The… Expand Rab GTPases regulate all stages of membrane trafficking, including vesicle budding, cargo sorting, transport, tethering and… Expand The remarkable degree of specificity with which Rab GTPases recognise distinct subsets of intracellular membranes forms the basis… Expand Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that… Expand SummaryThe Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a… Expand