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Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin*
TLDR
It is proposed that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of secretory vesicles at the release sites. Expand
Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.
TLDR
Data provide further support for a model in which malonyl-CoA and long chain acyl-CoAs esters serve as metabolic coupling factors when pancreatic beta-cells are stimulated with glucose and other nutrient secretagogues. Expand
Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic β-Cells
TLDR
MiR-21, miR-34a, andmiR-146a are identified as novel players in β-cell failure elicited in vitro and in vivo by proinflammatory cytokines, notably during the development of peri-insulitis that precedes overt diabetes in NOD mice. Expand
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
TLDR
It is shown that two non-coding microRNAs, miR124a and miR96, modulate the expression of proteins involved in insulin exocytosis and affect secretion of the β-cell line MIN6B1. Expand
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.
TLDR
The data suggest that Rab27a and Slac2c/MyRIP are part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton and participate to the regulation of the final steps of insulin exocytosis. Expand
Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.
TLDR
Observations indicate that granuphilins play an important role in pancreatic beta-cell exocytosis, and suggest that the postulated role of Munc-18 in secretory vesicle docking, may also be involved in this process. Expand
Fast Subplasma Membrane Ca2+ Transients Control Exo-Endocytosis of Synaptic-Like Microvesicles in Astrocytes
TLDR
The main findings indicate that exo-endocytosis in astrocytes proceeds with a time course on the millisecond time scale, and a role of this process in fast synaptic modulation is supported. Expand
SNAP-25 is expressed in islets of Langerhans and is involved in insulin release
TLDR
A role for SNAP-25 in fusion of dense core secretory granules with the plasma membrane in an endocrine cell type- the pancreatic B cell is suggested. Expand
Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice
TLDR
It is suggested that changes in the level of miR-29 family members contribute to cytokine-mediated β-cell dysfunction occurring during the initial phases of type 1 diabetes. Expand
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