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RPS6KB1 gene

Known as: p70 S6 KINASE, ALPHA, S6K1, p70(S6K)-ALPHA 
This gene is involved in protein phosphorylation.
National Institutes of Health

Related topics

Related topics

7 relations
PhosphorylationRPS6KA4 geneRibosomal Protein S6 Kinase Beta-1Serine/Threonine Phosphorylation

Narrower (1)

RPS6KB1 wt Allele

Papers overview

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Highly Cited
2018
Highly Cited
2018
Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation
Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are increasingly associated with… 
Highly Cited
2015
Highly Cited
2015
miR-195 Inhibits Tumor Progression by Targeting RPS6KB1 in Human Prostate Cancer
Purpose: To investigate the involvement of hsa-miRNA-195-5p (miR-195) in progression and prognosis of human prostate cancer… 
Highly Cited
2014
Highly Cited
2014
Modulation of hypoxia-signaling pathways by extracellular linc-RoR
ABSTRACT Resistance to adverse environmental conditions, such as hypoxia, contributes to the reduced efficacy of anticancer… 
Highly Cited
2014
Highly Cited
2014
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
Impaired autophagy function and enhanced ARG2 (arginase 2)-MTOR (mechanistic target of rapamycin) crosstalk are implicated in… 
Highly Cited
2013
Highly Cited
2013
Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.
PURPOSE Clinical studies have implicated the mechanistic target of rapamycin (serine/threonine kinase; MTOR) pathway in the… 
Highly Cited
2010
Highly Cited
2010
Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1–E2F pathway activity
The 40S ribosomal protein S6 kinase (S6K) is a conserved component of signalling pathways controlling growth in eukaryotes. To… 
2008
2008
Expressional changes in the intracellular melanogenesis pathways and their possible role in the pathogenesis of vitiligo.
Highly Cited
2007
Highly Cited
2007
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
S6K1 has emerged as a critical signaling component in the development of insulin resistance through phosphorylation and… 
Highly Cited
2004
Highly Cited
2004
S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
ABSTRACT Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth… 
Highly Cited
2003
Highly Cited
2003
Thermodynamically balanced inside-out (TBIO) PCR-based gene synthesis: a novel method of primer design for high-fidelity assembly of longer gene sequences.
A novel thermodynamically-balanced inside-out (TBIO) method of primer design was developed and compared with a thermodynamically… 
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