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RPS6KB1 wt Allele

Known as: p70-alpha, PS6K, p70(S6K)-alpha 
Human RPS6KB1 wild-type allele is located in the vicinity of 17q23.1 and is approximately 57 kb in length. This allele, which encodes ribosomal… 
National Institutes of Health

Related topics

Related topics

7 relations
17q23.1PhosphorylationRibosomal Protein S6 Kinase Beta-1Serine/Threonine Phosphorylation

Broader (1)

RPS6KB1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer
During the last decade it was established that conservative growth hormone/ insulin-like growth factor-1 (IGF-1) and target of… 
2013
2013
Effects of advanced age on whole-body protein synthesis and skeletal muscle mechanistic target of rapamycin signaling in horses.
OBJECTIVE To determine the effects of advanced age on whole-body protein synthesis and activation of the mechanistic target of… 
Review
2011
Review
2011
Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging
The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging… 
Highly Cited
2010
Highly Cited
2010
Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.
The mammalian target of rapamycin complex 1 (mTORC)1 pathway has emerged as a critical signaling component in the modulation of… 
2010
2010
Methionine deprivation regulates the S6K1 pathway and protein synthesis in avian QM7 myoblasts without activating the GCN2/eIF2 alpha cascade.
Amino acids modulate mRNA translation through the 70 kDa ribosomal protein S6 kinase (S6K1) and the general control… 
2009
2009
Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1…
Phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues has been recognized as a mechanism responsible for a… 
Review
2008
Review
2008
Modification of core body temperature by amino acid administration.
The feeling of warmth after a meal is caused by the ingestion of nutrients and the sensation is known as nutrition-induced… 
2007
2007
A Fas-Associated Death Domain Protein/Caspase-8-Signaling Axis Promotes S-Phase Entry and Maintains S6 Kinase Activity in T Cells Responding to IL-21
Fas-associated death domain protein (FADD) constitutes an essential component of TNFR-induced apoptotic signaling. Paradoxically… 
2006
2006
S6k1 is not required for Pten-deficient neuronal hypertrophy
Highly Cited
2005
Highly Cited
2005
Endotoxin disrupts the leucine‐signaling pathway involving phosphorylation of mTOR, 4E‐BP1, and S6K1 in skeletal muscle
Endotoxin (i.e., lipopolysaccharide, LPS) impairs skeletal muscle protein synthesis. Although this impairment is not acutely… 
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