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RPS6KB1 wt Allele

Known as: p70-alpha, PS6K, p70(S6K)-alpha 
Human RPS6KB1 wild-type allele is located in the vicinity of 17q23.1 and is approximately 57 kb in length. This allele, which encodes ribosomal… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR as an mTOR-interacting… Expand
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Highly Cited
2007
Highly Cited
2007
Alternative splicing modulates the expression of many oncogene and tumor-suppressor isoforms. We have tested whether some… Expand
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Highly Cited
2007
Highly Cited
2007
S6K1 has emerged as a critical signaling component in the development of insulin resistance through phosphorylation and… Expand
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Review
2006
Review
2006
Nutrient overload leads to obesity, insulin resistance, and often type 2 diabetes. Whereas increased fat intake is commonly cited… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals triggered by hormones, growth… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to regulate cell growth (increased cell… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The mammalian target of rapamycin (mTOR) controls the translation machinery via activation of S6 kinases 1 and 2 (S6K1… Expand
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Highly Cited
2002
Highly Cited
2002
The evolution of mitogenic pathways has led to the parallel requirement for negative control mechanisms, which prevent aberrant… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT Vertebrate TOP mRNAs contain an oligopyrimidine tract at their 5′ termini (5′TOP) and encode components of the… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Studies by comparative genomic hybridization (CGH) have shown that chromosomal region 17q23 is amplified in up to 20… Expand
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