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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. TwoExpand
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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their functional responses1–3. Stat4 was initiallyExpand
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines, and are thought to mediate many of their functional responses1–4. Stat6Expand
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Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
ABSTRACT The mammalian Toll-like receptor 4, TLR4, is an important component in the innate immune response to gram-negative bacterial infection. The role of TLR4 in antiviral immunity has beenExpand
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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.
Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thusExpand
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Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections
The rules for T‐cell‐mediated control of viruses that infect via the respiratory mucosae show both common themes and differences depending on the nature of the pathogen. Virus‐specific CD8+ cytotoxicExpand
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Human Metapneumovirus Persists in BALB/c Mice despite the Presence of Neutralizing Antibodies
ABSTRACT Human metapneumovirus (HMPV) has emerged as an important human respiratory pathogen causing upper and lower respiratory tract infections in young children and older adults. RecentExpand
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CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein
Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation thatExpand
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Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate.
A spectroscopic assay based on surface enhanced Raman scattering (SERS) using silver nanorod array substrates has been developed that allows for rapid detection of trace levels of viruses with a highExpand
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The Immune Response to Human Metapneumovirus Is Associated with Aberrant Immunity and Impaired Virus Clearance in BALB/c Mice
ABSTRACT Human metapneumovirus (HMPV), recently identified in isolates from children hospitalized with acute respiratory tract illness, is associated with clinical diagnosis of pneumonia, asthmaExpand
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