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RP 49356

Known as: RP-49356 
National Institutes of Health

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Broader (1)

aprikalim

Papers overview

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2004
2004
The potassium channel opener RP 49356 modifies the ATP-sensitivity of K+-ATP channels in cardiac myocytes
Introduct ion RP 49356, N-methyl-2-(3-pyridyl)-tetrahydrothiopyran -2-carbothioamide-l-oxide, is a potent vasorelaxant agent with… 
2004
2004
Comparison of the effects of RP 49356, cromakalim and nifedipine on guinea-pig tracheain vitro
Introduction RP 49356 and cromakalim (BRL 34915) relax various smooth muscle types by opening potassium (K +) channels in the… 
1996
1996
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.
AIM To study the effects of potassium channel openers (PCO) on cytosolic free calcium ([Ca2+]i) changes and their possible… 
1996
1996
Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells.
AIM To study the effects of pinacidil (Pin), nicorandil (Nic), RP 49356 (RP), and lemakalim (Lem) on phenylephrine (PE)-induced… 
Highly Cited
1993
Highly Cited
1993
4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers.
This study describes the in vitro and in vivo characteristics of a guanidine 4-morpholinecarboximidine-N-1-adamantyl-N… 
1993
1993
Synergistic effects of glyburide and U-37883A, two structurally different vascular ATP-sensitive potassium channel antagonists.
Glyburide, a sulfonylurea, and U-37883A, a guanidine (4-Morpholinecarboximidine-N-1-Adamantyl-N' cyclohexylhydrochloride), have… 
1992
1992
Differential effects of endothelin‐1 on the vasorelaxant properties of benzopyran and non‐benzopyran potassium channel openers
1 . The effects of endothelin‐1 (ET‐1) on the vasorelaxant properties of structurally different potassium channel openers (PCOs… 
Review
1990
Review
1990
The potassium channel openers: a new class of vasorelaxants.
Cromakalim, pinacidil, nicorandil, diazoxide and RP-49356 belong to the class of drugs termed potassium channel openers. In rat… 
1990
1990
Effects of potassium channel openers on single potassium channels in mouse skeletal muscle
SummaryThe patch-clamp technique was used to study the effects of the potassium channel openers cromakalim, pinacidil, RP 49356… 
Highly Cited
1989
Highly Cited
1989
K+ channels openers prevent epilepsy induced by the bee venom peptide MCD.
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