• Publications
  • Influence
Pathogenesis of Cardiovascular Alterations in Dogs Treated with Minoxidil 1
Minoxidil-induced cardiovascular lesions were not prevented by treatment with a β-blocker (propranolol), or an α-blockers (dibenzylene), or by sympathetic neural activity suppression (surgical sympathectomy or constant carotid sinus nerve stimulation), suggesting that the sympathetic response to the pharmacologic activity of minoxidill was not responsible for the induction of the cardiovascular lesions. Expand
4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers.
U-37883A thus appears to be the first nonsulfonylurea shown to block consistently and selectively the in vitro as well as the in vivo pharmacological responses to various potassium channel openers. Expand
Evidence for a central sympathoexcitatory action of alpha-2 adrenergic antagonists.
Data indicate that low doses of the alpha-2 receptor antagonist piperoxane and rauwolscine act centrally to increase SND and the nature of the interactions between central noradrenergic neurons and neurons involved in the genesis of sympathetic nerve activity is discussed. Expand
Pharmacology of the K‐ATP Channel Blocking Morpholinoguanidine PNU‐37883A
The last two decades have seen enormous growth in our understanding of ion channel structure and function. In particular, adenosine-5 '-triphosphate-sensitiv e potassium (K-ATP) channels have beenExpand
Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity.
It is concluded that central 5-HT neurons facilitate transmission in central sympathetic pathways in cats studied, and 5- HT agonists and antagonists both mediate a central reduction in SND. Expand
Whole body and regional hemodynamic effects of minoxidil in the conscious dog.
These experiments establish minoxidil's relative vasodilation in the major tissue beds of the dog which contributes to its hypotensive activity. Expand
Renal and Vascular Effects of Chemically Distinct ATP‐Sensitive K+ Channel Blockers in Rats
The first in vivo suggestion of structural differences among the channel and/or accessory proteins from this family of K+-selective channels is suggested, suggesting common features between ATP-sensitive K+ channels in vascular smooth muscle (VSM) and renal tubules. Expand
Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines.
U-45194A is identified as a less cardiac depressant analog having U-37883A-like diuretic and functional K-ATP channel blocking activities, which reduces LV stroke volume and increased peripheral vascular resistance in conscious dogs. Expand
Cardiovascular and Electrocardiographic Effects of the Dopamine Receptor Agonists Ropinirole, Apomorphine, and PNU-142774E in Conscious Beagle Dogs
It is established that in conscious dogs, the selective dopamine receptor agonist PNU-142774E has fewer cardiovascular and emetic effects than ropinirole and apomorphine and supports prior in vitro findings that ropinisrole and Apomorphine but not the PNu-14 2774E imidazoquinolin analog sumanirole reduces the delayed rectifier current in HERG transfected cells. Expand
Evidence for a central depressor action of postsynaptic α1-adrenergic receptor antagonists
The data indicate that the sympatholytic action of WB-4101 and prazosin results from a centrally mediated reduction in SND as well as a peripheral blockade of α-adrenergic receptors, and suggest that noradrenaline neurons normally facilitate the outflow of sympathetic nerve activity from the central nervous system. Expand