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Alfuzosin, a selective α1‐adrenoceptor antagonist in the lower urinary tract
Alfuzosin is a potent selective α1‐adrenoceptor antagonist in tissues of the lower urinary tract including the human prostate and provides a pharmacological basis for its use in the treatment of benign prostatic hypertrophy.
The pharmacology of RS‐15385‐197, a potent and selective α2‐adrenoceptor antagonist
RS‐15385‐197 was devoid of affinity for the non‐adrenoceptor imidazoline binding site, labelled by [3H]‐idazoxan, which provides further evidence that these sites are not related to α2‐ adrenoceptors.
Changes in vascular reactivity in experimental hypertensive animals following treatment with indapamide
- L. Finch, P. Hicks, R. Moore
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 1 September 1977
The results support a vascular site of action for indapamide and suggest a mode of action different from that of hydrochlorothiazide that is supported by a study of conscious renal hypertensive cats and DOCA/saline hypertensive rats.
Antagonism by tetrahydro-beta-carboline of the vasoconstrictor responses to tryptamine in rat tail arteries.
5HT-receptor antagonist properties of SCH 23390 in vascular smooth muscle and brain.
Differential effects of α-β-methylene ATP on responses to nerve stimulation in SHR and WKY tail arteries
- M. Vidal, P. Hicks, S. Z. Langer
- Medicine, BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 April 1986
The results suggest a significantly greater cotransmitter role for ATP with noradrenaline in tail arteries of SHR compared with control normotensive WKY rats, and additional effects of α,β-methylene ATP not involving P2 receptors cannot be entirely excluded.
Calcium Channel Receptor Binding Studies for Diltiazem and Its Major Metabolites: Functional Correlation to Inhibition of Portal Vein Myogenic Activity
- H. Schoemaker, P. Hicks, S. Z. Langer
- Biology, ChemistryJournal of cardiovascular pharmacology
- 1 February 1987
Pharmacologically distinct but allosterically interacting calcium channel antagonist binding sites have recently been identified using radiolabeled dihydropyridine derivatives (e.g.,…
α‐Adrenoceptor subtypes in dog saphenous vein that mediate contraction and inositol phosphate production
- P. Hicks, M. Barras, G. Herman, P. Mauduit, J. Armstrong, B. Rossignol
- Biology, ChemistryBritish journal of pharmacology
- 1 January 1991
Contractile responses to the α‐adrenoceptor agonists phenylephrine, cirazoline or BHT‐920 in dog isolated saphenous vein rings, using the antagonists yohimbine (Yoh), idazoxan (Idaz), prazosin (Praz), WB‐4101 (WB) and nitrendipine or zero Ca2+ medium are studied.
The cardiovascular effects of intraventricularly administered histamine in the anaesthetised rat
The results suggest that histamine is able to modify the resting blood pressure and heart rate by independent central modes of action, which involve central adrenergic and cholinergic mechanisms.
Alpha-adrenoreceptor subtypes in blood vessels: physiology and pharmacology.
In spontaneously hypertensive rats, smooth-muscle alpha 2-adrenoreceptors mediate vasoconstrictor responses to exogenous noradrenaline and to sympathetic nerve stimulation to a greater extent than in the corresponding normotensive Wystar-Kyoto rats, which may point to a pathophysiological role of these alpha 2/2 subtypes in hypertension.