• Publications
  • Influence
K+ is an endothelium-derived hyperpolarizing factor in rat arteries
The results show that fluctuations in K+ levels originating within the blood vessel itself are important in regulating mammalian blood pressure and flow. Expand
EDHF: bringing the concepts together.
Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review. Expand
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxideExpand
The pharmacology of ATP-sensitive potassium channels.
Type 1 KATP channels are essentially calciumand voltage-independent, K+ -selective, and are half-maximally inhibited by [ATP]i in the range 10-100 fJ, and exhibit inward rectification and a key pharmacological feature is their inhibition by agents like tolbutamide and glyburide. Expand
Characterization of an apamin‐sensitive small‐conductance Ca2+‐activated K+ channel in porcine coronary artery endothelium: relevance to EDHF
The porcine coronary artery endothelium expresses an apamin‐sensitive SKCa containing the SK3 subunit, which is likely to confer all or part of the apamin•sensitive component of the endothelia‐derived hyperpolarizing factor (EDHF) response. Expand
Effects of methyl β‐cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin‐rich domains
The small and intermediate conductance, Ca2+‐sensitive K+ channels (SKCa and IKCa, respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae inExpand
Evidence in Favor of a Calcium-Sensing Receptor in Arterial Endothelial Cells: Studies With Calindol and Calhex 231
Raising extracellular Ca2+ or adding calindol, a CaSR agonist, produced concentration-dependent hyperpolarizations of vascular myocytes, actions attenuated by Calhex 231, a negative allosteric modulator of CaSR. Expand
Studies on the effects of anandamide in rat hepatic artery
It was concluded that anandamide is not EDHF in the rat hepatic artery and that Anandamide‐induced hyperpolarization is exerted indirectly and requires the presence of the endothelium. Expand
Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle
It is concluded that NS 1619 activates the large conductance, Ca2+‐sensitive channel, BKCa and over the same concentration range it inhibits both Kv and L‐type Ca‐channels. Expand
Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses.
PVAT from BKCa or adiponectin knockout mice failed to elicit an anticontractile response in wild-type arteries, and its effect on vascular tone is mediated by activation of BK Ca channels on vascular smooth muscle cells and adipocytes and by endothelial mechanisms. Expand