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ROCK1 protein, human

Known as: Rho-Associated, Coiled-Coil Containing Protein Kinase 1, ROCK1, Rho-associated, coiled-coil containing protein kinase 1, human 
Encoded by human ROCK1 Gene, Rho-Associated Coiled-Coil Containing Protein Kinase 1 is a Ser/Thr kinase activated when bound to GTP-bound Rho. The… 
National Institutes of Health

Related topics

Related topics

12 relations
Cell AdhesionCytoskeletal ModelingIntegrin Signaling PathwayMyosin Phosphatase Pathway

Broader (2)

rho-Associated Kinase 1rho-Associated Kinases

Papers overview

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Highly Cited
2013
Highly Cited
2013
Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway
Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) and loss of neurons. Recently, a growing… 
Highly Cited
2012
Highly Cited
2012
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells.
Highly Cited
2006
Highly Cited
2006
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis
Ventricular myocyte hypertrophy is an important compensatory growth response to pressure overload. However, pathophysiological… 
Highly Cited
2005
Highly Cited
2005
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK
Background Statins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme… 
Highly Cited
2005
Highly Cited
2005
LIM-kinase 2 and Cofilin Phosphorylation Mediate Actin Cytoskeleton Reorganization Induced by Transforming Growth Factor-β*
Reorganization of the actin cytoskeleton in response to growth factor signaling, such as transforming growth factor β (TGF… 
Highly Cited
2005
Highly Cited
2005
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice
Background— Rho GTPase and its downstream target, Rho-associated kinase (ROCK), have been implicated in diverse cardiovascular… 
Highly Cited
2001
Highly Cited
2001
RhoA is required for monocyte tail retraction during transendothelial migration
Transendothelial migration of monocytes is the process by which monocytes leave the circulatory system and extravasate through… 
Highly Cited
2000
Highly Cited
2000
A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons
Highly Cited
1998
Highly Cited
1998
Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells
A critical role for the small GTPase Rho and one of its targets, p160ROCK (a Rho-associated coiled coil-forming protein kinase… 
Highly Cited
1998
Highly Cited
1998
p160ROCK mediates RhoA activation of Na–H exchange
The ubiquitously expressed Na–H exchanger, NHE1, acts downstream of RhoA in a pathway regulating focal adhesion and actin stress… 
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