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RNA, Small Interfering

Known as: RNA, Short Interfering, Short Interfering RNA, Interfering RNA, Small 
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be… Expand
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Highly Cited
2007
Highly Cited
2007
A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the… Expand
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Highly Cited
2005
Highly Cited
2005
Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool in analysis of protein function, but… Expand
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Highly Cited
2004
Highly Cited
2004
Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and… Expand
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Highly Cited
2004
Highly Cited
2004
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level… Expand
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Highly Cited
2004
Highly Cited
2004
Short RNAs mediate gene silencing, a process associated with virus resistance, developmental control and heterochromatin… Expand
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Highly Cited
2003
Highly Cited
2003
A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex that mediates target RNA cleavage. Here… Expand
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Highly Cited
2002
Highly Cited
2002
In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the presence of a double-stranded RNA (dsRNA… Expand
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Highly Cited
2002
Highly Cited
2002
Double-stranded RNAs ≈21 nucleotides long [small interfering RNA (siRNA)] are recognized as powerful reagents to reduce the… Expand
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Highly Cited
2001
Highly Cited
2001
We examined the role of ATP in the RNA interference (RNAi) pathway. Our data reveal two ATP-dependent steps and suggest that the… Expand
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