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RNA, Small Interfering

Known as: RNA, Short Interfering, Short Interfering RNA, Interfering RNA, Small 
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be… 
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Highly Cited
2007
Highly Cited
2007
A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the… 
Highly Cited
2005
Highly Cited
2005
Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool in analysis of protein function, but… 
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Highly Cited
2004
Highly Cited
2004
Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and… 
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Highly Cited
2004
Highly Cited
2004
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level… 
Highly Cited
2004
Highly Cited
2004
Short RNAs mediate gene silencing, a process associated with virus resistance, developmental control and heterochromatin… 
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Highly Cited
2003
Highly Cited
2003
A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex that mediates target RNA cleavage. Here… 
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Highly Cited
2002
Highly Cited
2002
In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the presence of a double-stranded RNA (dsRNA… 
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Highly Cited
2002
Highly Cited
2002
Double-stranded RNAs ≈21 nucleotides long [small interfering RNA (siRNA)] are recognized as powerful reagents to reduce the… 
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Highly Cited
2001
Highly Cited
2001
We examined the role of ATP in the RNA interference (RNAi) pathway. Our data reveal two ATP-dependent steps and suggest that the… 
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