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RNA, Small Interfering

Known as: RNA, Short Interfering, Short Interfering RNA, Interfering RNA, Small 
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi… Expand
National Institutes of Health

Related topics

Related topics

24 relations

Broader (2)

Antisense Elements (Genetics)RNA

Narrower (10)

Atu027CALAA-01PF-04523655Piwi-Interacting RNA
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Clinical Data Interchange Standards Consortium TerminologyIn BloodMicroRNAsProcess of secretion
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Papers overview

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Highly Cited
2011
Highly Cited
2011
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be… Expand
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Highly Cited
2007
Highly Cited
2007
Transvascular delivery of small interfering RNA to the central nervous system
A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the… Expand
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Highly Cited
2005
Highly Cited
2005
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.
Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool in analysis of protein function, but… Expand
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Highly Cited
2004
Highly Cited
2004
Genetic and Functional Diversification of Small RNA Pathways in Plants
Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and… Expand
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Highly Cited
2004
Highly Cited
2004
Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level… Expand
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Highly Cited
2004
Highly Cited
2004
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
Short RNAs mediate gene silencing, a process associated with virus resistance, developmental control and heterochromatin… Expand
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Highly Cited
2003
Highly Cited
2003
Asymmetry in the Assembly of the RNAi Enzyme Complex
A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex that mediates target RNA cleavage. Here… Expand
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Highly Cited
2002
Highly Cited
2002
Effective expression of small interfering RNA in human cells
In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the presence of a double-stranded RNA (dsRNA… Expand
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Highly Cited
2002
Highly Cited
2002
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
Double-stranded RNAs ≈21 nucleotides long [small interfering RNA (siRNA)] are recognized as powerful reagents to reduce the… Expand
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Highly Cited
2001
Highly Cited
2001
ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway
We examined the role of ATP in the RNA interference (RNAi) pathway. Our data reveal two ATP-dependent steps and suggest that the… Expand
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