RNA, Small Interfering

Known as: RNA, Short Interfering, Short Interfering RNA, Interfering RNA, Small 
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi… (More)
National Institutes of Health

Related topics

Related topics

24 relations

Broader (2)

Antisense Elements (Genetics)RNA

Narrower (10)

Atu027CALAA-01PF-04523655Piwi-Interacting RNA
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Clinical Data Interchange Standards Consortium TerminologyIn BloodMicroRNAsProcess of secretion
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Papers overview

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Review
2017
Review
2017
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
RNA interference (RNAi) is a natural cellular mechanism that inhibits gene expression in a sequence-specific manner. In the last… (More)
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Highly Cited
2007
Highly Cited
2007
Transvascular delivery of small interfering RNA to the central nervous system
A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the… (More)
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Highly Cited
2005
Highly Cited
2005
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
Short interfering RNA (siRNA) is used in RNA interference technology to avoid non-target-related induction of type I interferon… (More)
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Highly Cited
2005
Highly Cited
2005
DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana.
Arabidopsis thaliana contains four DICER-LIKE (DCL) genes with specialized functions in small RNA biogenesis for RNA interference… (More)
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Highly Cited
2004
Highly Cited
2004
Genetic and Functional Diversification of Small RNA Pathways in Plants
Multicellular eukaryotes produce small RNA molecules (approximately 21-24 nucleotides) of two general types, microRNA (miRNA) and… (More)
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Highly Cited
2004
Highly Cited
2004
Small interfering RNA-induced transcriptional gene silencing in human cells.
Small interfering RNA (siRNA) and microRNA silence genes at the transcriptional, posttranscriptional, and/or translational level… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.
Double-stranded RNAs approximately 21 nucleotides long [small interfering RNA (siRNA)] are recognized as powerful reagents to… (More)
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Highly Cited
2002
Highly Cited
2002
Two classes of short interfering RNA in RNA silencing.
RNA silencing is a eukaryotic genome defence system that involves processing of double-stranded RNA (dsRNA) into 21-26 nt, short… (More)
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Highly Cited
2002
Highly Cited
2002
Effective expression of small interfering RNA in human cells
In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the presence of a double-stranded RNA (dsRNA… (More)
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Highly Cited
2001
Highly Cited
2001
ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway
We examined the role of ATP in the RNA interference (RNAi) pathway. Our data reveal two ATP-dependent steps and suggest that the… (More)
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