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Atu027

Known as: Anti-PKN3 siRNA Atu027 
A lipoplexed formulation consisting of short-interfering RNAs (siRNAs) directed against protein kinase N3 (PKN3) encapsulated in catiogenic and… Expand
National Institutes of Health

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Related topics

1 relation

Broader (1)

RNA, Small Interfering

Papers overview

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2017
2017
First-in-human phase I study of the liposomal RNAi therapeutic Atu027 in patients with advanced cancer.
2508 Background: Atu027 is a novel vascular stabilising, anti-metastatic, RNAi therapeutic, targeting systemic endothelial cell… Expand
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2016
2016
A phase Ib/IIa study of combination therapy with gemcitabine and Atu027 in patients with locally advanced or metastatic pancreatic adenocarcinoma.
385 Background: Atu027 is a liposomally formulated short interfering RNA with anti-metastatic activity, which silences expression… Expand
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2016
2016
Gastrointestinal Cancers Symposium : update on pancreatic cancer
Agent Mechanism of action/target 196 [9] BBI-608 Cancer stemness inhibitor 341 [10] Demcizumab Humanized anti-DLL4 antibody 334… Expand
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Highly Cited
2014
Highly Cited
2014
First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
PURPOSE Atu027 is a novel liposomal RNA interference therapeutic that includes a short-interfering RNA (siRNA), which silences… Expand
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2014
2014
siRNA nanoparticles: the future of RNAi therapeutics for oncology?
siRNA clinical trials: state of the art With the emergence of siRNA-based nanomedicine as a powerful therapeutic strategy for… Expand
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2012
2012
Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.
Chemically synthesized, small interfering RNAs (siRNA) are currently used as a new class of therapeutic molecules, allowing the… Expand
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2012
2012
Antimetastatic activity of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3): Final results of a phase I study in patients with advanced solid tumors.
e13597 Background: Atu027 contains siRNA-lipoplexes, which elicits RNAi mediated suppression on PKN3 in vascular endothelial… Expand
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2011
2011
First-in-human phase I study of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3) in patients with advanced solid tumors.
3057 Background: Atu027 is a novel RNAi therapeutic based on cationic lipoplexes containing chemically stabilized siRNAs, which… Expand
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2010
2010
Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.
PURPOSE Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate… Expand
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Highly Cited
2008
Highly Cited
2008
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.
We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the… Expand
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