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Atu027
Known as:
Anti-PKN3 siRNA Atu027
A lipoplexed formulation consisting of short-interfering RNAs (siRNAs) directed against protein kinase N3 (PKN3) encapsulated in catiogenic and…
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
RNA, Small Interfering
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market
R. Titze-de-Almeida
,
Catherine David
,
Simoneide S Titze-de-Almeida
Pharmaceutical Research
2017
Corpus ID: 4925216
Ten years after Fire and Melo’s Nobel Prize for discovery of gene silencing by double-stranded RNA, a remarkable progress was…
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2016
2016
A phase Ib/IIa study of combination therapy with gemcitabine and Atu027 in patients with locally advanced or metastatic pancreatic adenocarcinoma.
B. Schultheis
,
D. Strumberg
,
+7 authors
U. Pelzer
2016
Corpus ID: 78692081
385 Background: Atu027 is a liposomally formulated short interfering RNA with anti-metastatic activity, which silences expression…
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Highly Cited
2014
Highly Cited
2014
First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
B. Schultheis
,
D. Strumberg
,
+8 authors
J. Drevs
Journal of clinical oncology : official journal…
2014
Corpus ID: 25548042
PURPOSE Atu027 is a novel liposomal RNA interference therapeutic that includes a short-interfering RNA (siRNA), which silences…
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2014
2014
siRNA nanoparticles: the future of RNAi therapeutics for oncology?
S. Chou
,
A. J. Mixson
Nanomedicine
2014
Corpus ID: 23162146
siRNA clinical trials: state of the art With the emergence of siRNA-based nanomedicine as a powerful therapeutic strategy for…
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2013
2013
First-in-human phase I study of the liposomal RNAi therapeutic Atu027 in patients with advanced cancer.
B. Schultheis
,
D. Strumberg
,
+5 authors
J. Kaufmann
2013
Corpus ID: 198287259
2508 Background: Atu027 is a novel vascular stabilising, anti-metastatic, RNAi therapeutic, targeting systemic endothelial cell…
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Highly Cited
2012
Highly Cited
2012
Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.
D. Strumberg
,
B. Schultheis
,
+6 authors
J. Drevs
International journal of clinical pharmacology…
2012
Corpus ID: 36895631
Chemically synthesized, small interfering RNAs (siRNA) are currently used as a new class of therapeutic molecules, allowing the…
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2012
2012
Antimetastatic activity of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3): Final results of a phase I study in patients with advanced solid tumors.
D. Strumberg
,
B. Schultheis
,
+7 authors
J. Drevs
2012
Corpus ID: 86537058
e13597 Background: Atu027 contains siRNA-lipoplexes, which elicits RNAi mediated suppression on PKN3 in vascular endothelial…
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2011
2011
First-in-human phase I study of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3) in patients with advanced solid tumors.
D. Strumberg
,
B. Schultheis
,
+6 authors
J. Drevs
Journal of clinical oncology : official journal…
2011
Corpus ID: 7249736
3057 Background: Atu027 is a novel RNAi therapeutic based on cationic lipoplexes containing chemically stabilized siRNAs, which…
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Highly Cited
2010
Highly Cited
2010
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
A. Santel
,
M. Aleku
,
+15 authors
J. Kaufmann
Clinical Cancer Research
2010
Corpus ID: 207695371
Purpose: Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate…
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Highly Cited
2008
Highly Cited
2008
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.
M. Aleku
,
P. Schulz
,
+19 authors
J. Kaufmann
Cancer research
2008
Corpus ID: 15137881
We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the…
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