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National Institutes of Health
RNA, Small Interfering
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Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
Proceedings of the National Academy of Sciences
Corpus ID: 15076181
Significance CALAA-01 is a targeted nanoparticle containing siRNA that is a first-in-class experimental therapeutic for cancer…
siRNA nanoparticles: the future of RNAi therapeutics for oncology?
A. J. Mixson
Corpus ID: 23162146
siRNA clinical trials: state of the art With the emergence of siRNA-based nanomedicine as a powerful therapeutic strategy for…
Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study.
Aaron C. Eifler
Methods in molecular biology
Corpus ID: 24647609
The approval of drugs for human use by the US Food and Drug Administration (FDA) through the Center for Drug Evaluation and…
RNA interference advances to early-stage clinical trials.
Journal of the National Cancer Institute
Corpus ID: 41804915
S ince the discovery of RNA interference (RNAi) in 1998, researchers have hoped to use the gene-silencing technique to shut down…
The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.
Mark E. Davis
Corpus ID: 22164615
Experimental therapeutics developed to exploit RNA interference (RNAi) are now in clinical studies. Here, the translation from…
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