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RGS Proteins

Known as: Regulators of G Protein Signaling Proteins, RGS Protein, RGS Family Protein 
RGS family proteins activate GTPase and regulate G protein signaling by stimulating the inactivation of heterotrimeric G proteins. RGS family… 
National Institutes of Health

Related topics

Related topics

23 relations
G Protein-Coupled Receptor SignalingIn BloodLigand BindingProcess of secretion

Broader (2)

GTP Phosphohydrolase ActivatorsGTPase-Activating Proteins

Narrower (7)

R7BP protein, mouseRGS1 protein, humanRGS2 protein, humanRGS2 protein, rat

Papers overview

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Highly Cited
2013
Highly Cited
2013
Structural and functional analysis of the regulator of G protein signaling 2-gαq complex.
Review
2009
Review
2009
R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.
Highly Cited
2005
Highly Cited
2005
Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells
The coupling of GABAB receptors to G-protein-gated inwardly rectifying potassium (GIRK) channels constitutes an important… 
Highly Cited
2003
Highly Cited
2003
Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities
Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs… 
Highly Cited
2003
Highly Cited
2003
Promotion of Gαi3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP
We have isolated an RGS-GAIP interacting protein that links RGS proteins to protein degradation. GIPN (GAIP interacting protein N… 
Highly Cited
2001
Highly Cited
2001
Characterization of RGS5 in regulation of G protein-coupled receptor signaling.
Highly Cited
2000
Highly Cited
2000
Cytoplasmic, Nuclear, and Golgi Localization of RGS Proteins
RGS proteins comprise a family of proteins named for their ability to negatively regulate heterotrimeric G protein signaling… 
Highly Cited
1998
Highly Cited
1998
GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP.
We have identified a mammalian protein called GIPC (for GAIP interacting protein, C terminus), which has a central PDZ domain and… 
Highly Cited
1998
Highly Cited
1998
RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles.
RGS-GAIP (Galpha-interacting protein) is a member of the RGS (regulator of G protein signaling) family of proteins that functions… 
Highly Cited
1998
Highly Cited
1998
GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain*
Regulator of G-protein signaling (RGS) proteins increase the intrinsic guanosine triphosphatase (GTPase) activity of G-protein… 
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