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RECQL gene

Known as: RECQL1, RecQ like helicase, RECQ PROTEIN-LIKE 
This gene is involved in DNA unwinding and the promotion of DNA strand annealing.
National Institutes of Health

Related topics

Related topics

7 relations
DNA RepairDNA ReplicationGenetic Translation ProcessHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Catalytic Strand Separation by RECQ1 Is Required for RPA-Mediated Response to Replication Stress
2014
2014
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion
The RECQ protein family of helicases has critical roles in protecting and stabilizing the genome. Three of the 5 known members of… 
Highly Cited
2013
Highly Cited
2013
Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks
Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding… 
Highly Cited
2011
Highly Cited
2011
RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.
RECQL1 and WRN proteins are RecQ DNA helicases that participate in suppression of DNA hyper-recombination and repair. In this… 
2011
2011
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation
BackgroundRecQ helicases play an essential role in the maintenance of genome stability. In humans, loss of RecQ helicase function… 
Highly Cited
2007
Highly Cited
2007
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges
Background DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding… 
Highly Cited
2007
Highly Cited
2007
Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)‐siRNA Conjugate Formulated in PEGylated Polyplexes
PEGylated polyplexes (lac‐PEGylated polyplexes) composed of poly(L‐lysine) and lactosylated poly(ethylene glycol)‐small… 
Highly Cited
2005
Highly Cited
2005
Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines
Homologous recombination provides an effective way to repair DNA double-strand breaks (DSBs) and is required for genetic… 
Highly Cited
2002
Highly Cited
2002
Mutation profiling of mismatch repair-deficient colorectal cncers using an in silico genome scan to identify coding microsatellites.
Human colorectal, endometrial, and gastric cancers with defective DNA mismatch repair (MMR) have microsatellite instability, a… 
Highly Cited
1994
Highly Cited
1994
Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.
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