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RBX1 gene

Known as: Ring-Box 1 Gene, ROC1, REGULATOR OF CULLINS 1 
This gene plays a critical role in ubiquitination.
National Institutes of Health

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Ligand BindingProtein Degradation, MetabolicRBX1 protein, humanTumor Suppression

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RBX1 wt Allele

Papers overview

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2016
2016
Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5
Abstract The CSN complex plays a key role in various cellular pathways: through a metalloprotease activity of its Csn5… 
2015
2015
Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro.
2015
2015
A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region
We isolated a new recessive allele at the AUXIN RESISTANT6/CULLIN1 (AXR6/CUL1) locus, axr6–101, from an EMS-mutagenized… 
2012
2012
Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation.
2011
2011
Identification and functional characterization of an Rbx1 in an invertebrate Haliotis diversicolor supertexta.
2010
2010
No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer
AbstractpVHL is the central component of an ubiquitin ligase complex that targets hypoxia-inducible factor 1α (HIF-1α) for… 
2009
2009
Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen
Purpose: A major impediment in the optimal selection of cancer patients for the most effective therapy is the lack of suitable… 
2001
2001
ccurrence of a Putative SCF Ubiquitin igase Complex in Drosophila ilvia
t g u s p m u l c a p g l a p s r t E p W e s d h s Many proteins are targeted to proteasome degradaion by a family of E3… 
2000
2000
SCFβ-TRCP and phosphorylation dependent ubiquitination of IκBα catalyzed by Ubc3 and Ubc4
NFκB is an important transcriptional regulator of multiple pro-inflammatory genes. In non-stimulated cells NFκB is anchored in… 
2000
2000
SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.
NF kappa B is an important transcriptional regulator of multiple pro-inflammatory genes. In non-stimulated cells NF kappa B is… 
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