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Gene expression profiling predicts clinical outcome of breast cancer
TLDR
DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy. Expand
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
TLDR
It is shown that siRNA expression mediated by this vector causes efficient and specific down-regulation of gene expression, resulting in functional inactivation of the targeted genes. Expand
The Consensus Molecular Subtypes of Colorectal Cancer
TLDR
An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features. Expand
A Genomic and Functional Inventory of Deubiquitinating Enzymes
TLDR
An inventory of the deubiquitinating enzymes encoded in the human genome is presented and the literature concerning these enzymes is reviewed, with particular emphasis on their function, specificity, and the regulation of their activity. Expand
A gene-expression signature as a predictor of survival in breast cancer.
TLDR
The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria. Expand
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
TLDR
An RNA-interference-based genetic screen in human cells is performed to search for kinases whose knockdown synergizes with BRAF(V600E) inhibition, and it is reported that blockade of the epidermal growth factor receptor (EGFR) shows strong synergy with BRAFs inhibition. Expand
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
TLDR
Assessment of PI3K pathway activation may provide a biomarker to identify patients unlikely to respond to trastuzumab-based therapy, and the combined analysis of PTEN and PIK3CA identified twice as many patients at increased risk for progression compared to PTEN alone. Expand
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
TLDR
It is reported here that inhibition of one of these enzymes, the familial cylindromatosis tumour suppressor gene (CYLD), having no known function, enhances activation of the transcription factor NF-κB, and this effect can be relieved by aspirin derivatives that inhibit NF-σB activity. Expand
Regulation of monoubiquitinated PCNA by DUB autocleavage
TLDR
This work shows that the DUB ubiquitin specific protease 1 (USP1) deubiquitinates the DNA replication processivity factor, PCNA, as a safeguard against error-prone translesion synthesis (TLS) of DNA. Expand
Protein phosphatase 2A regulatory subunits and cancer.
TLDR
In this review, the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways are summarized andPP2A function in the regulation of MAPK and Wnt signaling is highlighted. Expand
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