Gene expression profiling predicts clinical outcome of breast cancer
- L. J. Veer, H. Dai, S. Friend
- Medicine, BiologyNature
- 31 January 2002
DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
The Consensus Molecular Subtypes of Colorectal Cancer
- J. Guinney, R. Dienstmann, S. Tejpar
- BiologyNature Network Boston
- 13 September 2015
An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
- T. Brummelkamp, R. Bernards, R. Agami
- BiologyScience
- 21 March 2002
It is shown that siRNA expression mediated by this vector causes efficient and specific down-regulation of gene expression, resulting in functional inactivation of the targeted genes.
A Genomic and Functional Inventory of Deubiquitinating Enzymes
- S. Nijman, M. Luna-Vargas, R. Bernards
- BiologyCell
- 2 December 2005
A gene-expression signature as a predictor of survival in breast cancer.
- M. J. van de Vijver, Yudong D. He, R. Bernards
- MedicineNew England Journal of Medicine
- 19 December 2002
The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
- A. Prahallad, Chong Sun, R. Bernards
- Biology, MedicineNature
- 26 January 2012
An RNA-interference-based genetic screen in human cells is performed to search for kinases whose knockdown synergizes with BRAF(V600E) inhibition, and it is reported that blockade of the epidermal growth factor receptor (EGFR) shows strong synergy with BRAFs inhibition.
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
- K. Berns, H. Horlings, R. Bernards
- Biology, MedicineCancer Cell
- 16 October 2007
Regulation of monoubiquitinated PCNA by DUB autocleavage
- Tony T. Huang, S. Nijman, A. D’Andrea
- BiologyNature Cell Biology
- 12 March 2006
This work shows that the DUB ubiquitin specific protease 1 (USP1) deubiquitinates the DNA replication processivity factor, PCNA, as a safeguard against error-prone translesion synthesis (TLS) of DNA.
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
- S. Friend, R. Bernards, T. Dryja
- Biology, MedicineNature
- 16 October 1986
The isolation of a complementary DNA segment that detects a chromosomal segment having the properties of the gene at this locus is described, which is expressed in many tumour types, but no RNA transcript has been found in retinoblastomas and osteosarcomas.
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
- K. Stemke‐Hale, A. González-Angulo, B. Hennessy
- BiologyCancer Research
- 1 August 2008
PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes and the specific aberration present may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.
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