Tumor Suppression

Known as: Tumor Suppression, Molecular 
Tumor suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1961-2018
05010019612018

Papers overview

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Highly Cited
2008
Highly Cited
2008
Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and… (More)
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Highly Cited
2008
Highly Cited
2008
Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase… (More)
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Highly Cited
2007
Highly Cited
2007
The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility… (More)
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Highly Cited
2007
Highly Cited
2007
Like apoptosis, oncogene-induced senescence is a barrier to tumor development. However, relatively little is known about the… (More)
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Highly Cited
2006
Highly Cited
2006
Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor… (More)
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Highly Cited
2005
Highly Cited
2005
Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by… (More)
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Highly Cited
2003
Highly Cited
2003
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and… (More)
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Highly Cited
2002
Highly Cited
2002
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene… (More)
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Highly Cited
2002
Highly Cited
2002
Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of hereditary (VHL Disease-associated… (More)
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Highly Cited
1998
Highly Cited
1998
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16INK4 binds to and inhibits the… (More)
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