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Tumor Suppression

Known as: Tumor Suppression, Molecular 
Tumor suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis.
National Institutes of Health

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ANP32C wt AlleleBAP1 geneBCPR GeneBCSC-1 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
BRCA Gene Structure and Function in Tumor Suppression: A Repair-Centric Perspective
Germline mutations in the BRCA1 and BRCA2 genes are characterized by deficient repair of DNA double-strand breaks by homologous… 
2006
2006
Critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression
Inactivation of the transforming growth factor-β (TGF-β) pathway occurs often in malignancies of the gastrointestinal (GI) system… 
Review
2004
Review
2004
Multi-functional gene ASY/Nogo/RTN-X/RTN4: Apoptosis, tumor suppression, and inhibition of neuronal regeneration
ASY, also designated Nogo, RTN-X, or RTN4, is a reticulon family protein containing two transmembrane domains and a C-terminal… 
Highly Cited
2001
Highly Cited
2001
Tumor suppression and potentiation by manipulation of pp32 expression
Alternative use of genes of the closely-related pp32 family is a common occurrence in human prostate cancer. pp32r1 and pp32r2… 
Highly Cited
2001
Highly Cited
2001
TGF-β signaling in tumor suppression and cancer progression
R Derynck, R J Akhurst & A Balmain Nature Genet. 29, 117–129 (2001). The label “p160ROCK” was incorrectly placed, owing to an… 
Highly Cited
1996
Highly Cited
1996
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.
Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions… 
Highly Cited
1996
Highly Cited
1996
Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.
The transcriptional activator IFN regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the IFN… 
1996
1996
Mechanisms of human melanoma cell growth and tumor suppression by chromosome 6.
Breaks and deletions of chromosome 6 are among the most frequent karyotypic abnormalities that appear in human malignant melanoma… 
Highly Cited
1995
Highly Cited
1995
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
The 9p21 region of human chromosome 9 is a hot spot for chromosomal aberrations in both cultured cell lines and primary tumors… 
1994
1994
Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells.
We have transfected the osteosarcoma cell line Saos2 and the bladder carcinoma cell line 5637 with additional retinoblastoma (RB… 
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