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TGF-beta signaling in tumor suppression and cancer progression.
TLDR
The role of TGF-beta is evaluated as both a tumor suppressor pathway and a promoter of tumor progression and invasion and the positive and negative effects of T GF-beta are attempted to reconcile. Expand
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
TLDR
Two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function. Expand
TGF-β signaling in tumor suppression and cancer progression
TLDR
The role of TGF-β is evaluated as both a tumor suppressor pathway and a promoter of tumor progression and invasion and the positive and negative effects of T GF-β in carcinogenesis are attempted. Expand
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
TLDR
A specific A→T transversion at the second nucleotide of codon 61 of the Harvey-ras (Ha-ras) gene is found, suggesting that the mutation occurs at the time of initiation of tumour progression. Expand
The genetics and genomics of cancer
TLDR
A deeper understanding of this disease will require new statistical and computational approaches for analysis of the genetic and signaling networks that orchestrate individual cancer susceptibility and tumor behavior. Expand
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
TLDR
It is shown that during multistage tumorigenesis, discrete expression thresholds of activated Smad2 and H-ras are sequentially surpassed, driving tumour progression through distinct phases from a differentiated squamous carcinoma to a motile invasive stage, followed by an overt change from epithelial to mesenchymal cell type. Expand
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
TLDR
The action of TGFbeta1 in enhancing malignant progression may mimic its proposed function in modulating epithelial cell plasticity during embryonic development. Expand
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
TLDR
It is reported here that a single dose of 4 Gy radiation dramatically decreases the latency for tumour development in p53 heterozygous mice, suggesting that there are additional genetic targets involved in radiation-induced malignancy. Expand
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
TLDR
A common genetic variant in STK15 (resulting in the amino acid substitution F31I) that is preferentially amplified and associated with the degree of aneuploidy in human colon tumors is identified and consistent with an important role for the Ile31 variant of STK 15 in human cancer susceptibility. Expand
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer.
TLDR
The transgenic adenocarcinoma of mouse prostate (TRAMP) model is widely used in prostate cancer research because of rapid tumor onset and progression, and neuroendocrine carcinomas are the principal malignancy in this model. Expand
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