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Molecular mechanisms of epithelial–mesenchymal transition
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral in development, wound healing and stem cell… Expand
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad… Expand
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, are… Expand
TGF-β-induced epithelial to mesenchymal transition
During development and in the context of different morphogenetic events, epithelial cells undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT). In this process,… Expand
Specificity and versatility in tgf-beta signaling through Smads.
The TGF-beta family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing Smad… Expand
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
AbstractThe TGF-β family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing Smad… Expand
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors
- P. J. Miettinen, R. Ebner, A. R. López, R. Derynck
- Biology, Medicine
- The Journal of cell biology
- 2 December 1994
The secreted polypeptide transforming growth factor-beta (TGF-beta) exerts its multiple activities through type I and II cell surface receptors. In epithelial cells, activation of the TGF-beta signal… Expand
TGF-beta signaling in tumor suppression and cancer progression.
Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation… Expand
TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression
Purpose of review TGF-&bgr; acts as a potent driver of cancer progression through the induction of epithelial–mesenchymal transition (EMT), in which epithelial cells acquire mesenchymal phenotype,… Expand
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
- D. Subramanyam, Samy Lamouille, +4 authors R. Blelloch
- Biology, Medicine
- Nature Biotechnology
- 1 May 2011
The embryonic stem cell–specific cell cycle–regulating (ESCC) family of microRNAs (miRNAs) enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. Here we show that… Expand