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Molecular mechanisms of epithelial–mesenchymal transition
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral in development, wound healing and stem cellExpand
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Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the SmadExpand
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Smad-dependent and Smad-independent pathways in TGF-β family signalling
Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, areExpand
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TGF-β-induced epithelial to mesenchymal transition
During development and in the context of different morphogenetic events, epithelial cells undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT). In this process,Expand
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Specificity and versatility in tgf-beta signaling through Smads.
The TGF-beta family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing SmadExpand
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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
AbstractThe TGF-β family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing SmadExpand
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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors
The secreted polypeptide transforming growth factor-beta (TGF-beta) exerts its multiple activities through type I and II cell surface receptors. In epithelial cells, activation of the TGF-beta signalExpand
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TGF-beta signaling in tumor suppression and cancer progression.
Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformationExpand
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TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression
Purpose of review TGF-&bgr; acts as a potent driver of cancer progression through the induction of epithelial–mesenchymal transition (EMT), in which epithelial cells acquire mesenchymal phenotype,Expand
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Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
The embryonic stem cell–specific cell cycle–regulating (ESCC) family of microRNAs (miRNAs) enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. Here we show thatExpand
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