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RAD50 gene

Known as: hRad50, RAD50, S. CEREVISIAE, HOMOLOG OF, RAD50 
This gene plays a role in DNA double-strand break repair.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDNA Topology RegulationDouble Strand Break RepairMeiotic Recombination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double‐strand breaks
The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of… 
2014
2014
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
The MRE11/RAD50/NBN (MRN) complex plays a key role in detecting DNA double-strand breaks, recruiting and activating ataxia… 
Highly Cited
2011
Highly Cited
2011
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair
The Rad50 ABC–ATPase complex with Mre11 nuclease is essential for dsDNA break repair, telomere maintenance and ataxia… 
2006
2006
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Highly Cited
2005
Highly Cited
2005
Effect of Amino Acid Substitutions in the Rad50 ATP Binding Domain on DNA Double Strand Break Repair in Yeast*
The Saccharomyces cerevisiae Rad50-Mre11-Xrs2 complex plays a central role in the cellular response to DNA double strand breaks… 
2003
2003
Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.
2001
2001
Frameshift Mutations at Mononucleotide Repeats in RAD50 Recombinational DNA Repair Gene in Colorectal Cancers with Microsatellite Instability
To identify additional genes targeted for microsatellite instability (MSI), we search for human genes which contain… 
Highly Cited
1998
Highly Cited
1998
Homologous recombination is required for the viability of rad27 mutants.
The RAD27/RTH1 gene of Saccharomyces cerevisiae encodes a structural and functional homolog of the 5'-3' exonuclease function of… 
Highly Cited
1996
Highly Cited
1996
Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae.
To examine the mechanism of illegitimate recombination in Saccharomyces cerevisiae, we have developed a plasmid system for… 
Highly Cited
1996
Highly Cited
1996
The repair of DNA methylation damage in Saccharomyces cerevisiae
Abstract The major genotoxicity of methyl methanesulfonate (MMS) is due to the production of a lethal 3-methyladenine (3MeA… 
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