• Publications
  • Influence
Human serum albumin: from bench to bedside.
TLDR
HSA is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control. Expand
Structure-function relationship of estrogen receptor alpha and beta: impact on human health.
TLDR
Understanding the structural basis and the molecular mechanisms by which ER transduce E2 signals in target cells will allow to create new pharmacologic therapies aimed at the treatment of a variety of human diseases affecting the cardiovascular system, the reproductive system and the skeletal system. Expand
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects.
TLDR
The purpose of this review is to highlight the structural and molecular bases of CAR and PXR impact on human health, providing information on mechanisms through which diet, chemical exposure, and environment ultimately impact health and disease. Expand
Estrogen signaling multiple pathways to impact gene transcription.
TLDR
This review will focus on the recent knowledge about the mechanism by which ERs regulate the expression of target genes and the emerging field of integration of membrane and nuclear receptor signaling, giving examples of the ways by which the genomic and non-genomic actions of ERs on target genes converge. Expand
AtCYS1, a cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death.
TLDR
The suppression of the NO-mediated cell death in plants overexpressing AtCYS1 provides the evidence that NO is not cytotoxic for the plant, indicating that NO functions as cell death trigger through the stimulation of an active process, in which cysteine proteases and theirs proteinaceous inhibitors appear to play a crucial role. Expand
The extraordinary ligand binding properties of human serum albumin
TLDR
The globular domain structural organization of monomeric HSA is at the root of its allosteric properties which are reminiscent of those of multimeric proteins. Expand
Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol.
TLDR
The physiological role of ERalpha palmitoylation in the receptor localization to the cell membrane and in the regulation of the E2-induced cell proliferation are found. Expand
A novel two‐over‐two α‐helical sandwich fold is characteristic of the truncated hemoglobin family
TLDR
Crystal structures of trHbs from the ciliated protozoan Paramecium caudatum and the green unicellular alga Chlamydomonas eugametos show that the tertiary structure of both proteins is based on a ‘two‐over‐two’ α‐helical sandwich, reflecting an unprecedented editing of the classical ‘three‐ over‐three’α‐helICAL globin fold. Expand
Common themes and variations in the rhodanese superfamily
TLDR
A superfamily of versatile proteins relying on persulfide chemistry to accomplish cellular functions spanning from resistance to environmental threats, such as cyanide, and key cellular reactions related to sulfur metabolism and progression of cell cycle is depicted. Expand
Structure–function relationship of estrogen receptor α and β: Impact on human health
TLDR
Understanding the structural basis and the molecular mechanisms by which ER transduce E2 signals in target cells will allow to create new pharmacologic therapies aimed at the treatment of a variety of human diseases affecting the cardiovascular system, the reproductive system, and the skeletal system. Expand
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