Skip to search formSkip to main contentSkip to account menu

R 59022

Known as: R 59-022, R-59 022, R59022 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Enzyme InhibitorsPyrimidinonesThiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways.
Transforming growth factor beta 1 (TGF-beta1) affects growth plate chondrocytes through Smad-mediated mechanisms and has been… 
1996
1996
Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores…
Effects of sphingosine on Ca2+ mobilization in the human Jurkat T cell line were examined. Sphingosine increased the cytoplasmic… 
1993
1993
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol…
The primary phase of ADP-induced aggregation of human platelets does not involve appreciable formation of thromboxane A2 or… 
Highly Cited
1990
Highly Cited
1990
Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with…
The generation of diradylglycerol (DRG) and phosphatidic acid (PdtOH) was investigated in neutrophils primed with granulocyte… 
1990
1990
Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation
To elucidate the transmembrane signalling processes initiated by fibroblast growth factor (FGF), we have studied the effect of… 
Highly Cited
1989
Highly Cited
1989
Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol
Highly Cited
1989
Highly Cited
1989
Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.
The relationships between the chemotactic factor-stimulated mobilization of calcium, activation of the NADPH-oxidase, changes in… 
1989
1989
Protein kinase C activation has dissimilar effects on sodium-coupled uptakes in renal proximal tubular cells in primary culture.
Protein kinase C (Ca2+/phospholipid-dependent enzyme) was shown to be present in renal brush border membranes. To evaluate the… 
Highly Cited
1987
Highly Cited
1987
A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts.
Treatment of Swiss-mouse 3T3 fibroblasts with a tumour-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA… 
1987
1987
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Human platelets were depleted of intracellular Ca2+ and then made selectively permeable to external Ca2+ by addition of the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)