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R 59022

Known as: R 59-022, R-59 022, R59022 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Enzyme InhibitorsPyrimidinonesThiazoles

Papers overview

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Highly Cited
2003
Highly Cited
2003
Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.
Highly Cited
2001
Highly Cited
2001
Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis.
The diacylglycerol (DAG) signal generated from membrane phospholipids by hormone-activated phospholipases is attenuated by… 
1993
1993
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol…
The primary phase of ADP-induced aggregation of human platelets does not involve appreciable formation of thromboxane A2 or… 
Highly Cited
1992
Highly Cited
1992
Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.
Highly Cited
1991
Highly Cited
1991
Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C.
The effects of phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), on high-affinity Na… 
Highly Cited
1990
Highly Cited
1990
Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with…
The generation of diradylglycerol (DRG) and phosphatidic acid (PdtOH) was investigated in neutrophils primed with granulocyte… 
Highly Cited
1989
Highly Cited
1989
Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol
Highly Cited
1989
Highly Cited
1989
Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.
The relationships between the chemotactic factor-stimulated mobilization of calcium, activation of the NADPH-oxidase, changes in… 
Highly Cited
1987
Highly Cited
1987
A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts.
Treatment of Swiss-mouse 3T3 fibroblasts with a tumour-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA… 
1987
1987
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Human platelets were depleted of intracellular Ca2+ and then made selectively permeable to external Ca2+ by addition of the… 
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