Pyrimidinones

The discovery of two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is… Expand

Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to… Expand

6.1. Oxadiazoles 4154 6.2. Diazaphospholes 4154 7. Six-Membered Heterocycles with One Heteroatom 4155 7.1. Pyridines 4155 7.2… Expand

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast… Expand

Evidence for an error-free DNA damage tolerance process in eukaryotes (also called postreplication repair) has existed for more… Expand

Mechanism-based inhibitors of enzymes, which mimic reactive intermediates in the reaction pathway, have been deployed extensively… Expand

Ceric ammonium nitrate efficiently catalyzes the three component condensation of an aldehyde, β-ketoester and urea in methanol to… Expand

This paper is a case history of the chemical development of sildenafil which covers various aspects of work in chemical… Expand

Rapid and regioselective activation of the C-F bond of 2,4,6-trifluoropyrimidine occurs on reaction with [Ni(cod)(2)] (cod=1,5… Expand

DNA duplexes in which the target cytosine base is replaced by 2-H pyrimidinone have previously been shown to bind with a… Expand