Pyrimidinones

Known as: Pyrimidinones [Chemical/Ingredient], pyrimidinone 
 
National Institutes of Health

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2,6-diaminopyrimidin-4-one2-amino-6-methylpyrimidin-4-one2-hydroxy-4,6-dimethylpyrimidine3-methyl-4-pyrimidone
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In Bloodagonistsantagonists & inhibitorschemical synthesis

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Pyrimidines

Papers overview

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2009
2009
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to… (More)
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2008
2008
Three-state conical intersections in cytosine and pyrimidinone bases.
Three-state conical intersections have been located and characterized for cytosine and its analog 5-methyl-2-pyrimidinone using… (More)
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2008
2008
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.
The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast… (More)
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2006
2006
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with… (More)
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Highly Cited
2005
Highly Cited
2005
The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination.
Evidence for an error-free DNA damage tolerance process in eukaryotes (also called postreplication repair) has existed for more… (More)
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Highly Cited
2002
Highly Cited
2002
Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.
Mechanism-based inhibitors of enzymes, which mimic reactive intermediates in the reaction pathway, have been deployed extensively… (More)
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2002
2002
Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives.
A series of pyrimidinone derivatives of thiazolidinediones were synthesized. Their biological activity were evaluated in insulin… (More)
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1999
1999
Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone.
DNA duplexes in which the target cytosine base is replaced by 2-H pyrimidinone have previously been shown to bind with a… (More)
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1983
1983
5-halo-6-phenyl pyrimidinones: new molecules with cancer therapeutic potential and interferon-inducing capacity are strong inducers of murine natural killer cells.
We tested the effect of three different interferon-(IFN) inducing pyrimidinone molecules with cancer therapeutic potential on… (More)
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1982
1982
Studies on the antitumor activities of pyrimidinone-interferon inducers. I. Effect against artificial and spontaneous lung metastases of murine tumors.
Since pyrimidinone compounds induce interferon production in several animal species and have potent antivirus activities, it… (More)
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