R 56865

The Na+-activated K+ current was studied in inside-out patches and in whole cells isolated from the guinea-pig cardiac ventricle… Expand

1 Persistent sodium channel activity was recorded before and during hypoxia from cell‐attached and inside‐out patches obtained… Expand

We investigated protective effects of KB‐R7943, a Na+/Ca2+ exchange (NCX) inhibitor, on ouabain‐induced tonotropy and arrhythmias… Expand

We hypothesized that by limiting the Na+ and Ca2+ loading by a blocker/inhibitor of the Na+ channel (lidocaine), Na+ overload… Expand

Abstract The inhibitors of the Na+/H+-exchange (NHE1) system Hoe 694 and Hoe 642 possess cardioprotective effects in ischaemia… Expand

Anoxic depolarization (AD) and failure of ion homeostasis play an important role in ischemia-induced neuronal injury. In the… Expand

We present in this report the characteristics of the damage induced by 6-hydroxydopamine and H2O2 on bovine chromaffin cells in… Expand

In a perfused guinea-pig heart model of myocardial ischaemia, reducing coronary flow by 95% for four successive 6 min periods… Expand

Intracellular Ca2+ overload is considered to be the final pathway leading to cell death under pathological conditions. However… Expand

The antiarrhythmic effects of R56865 were characterized both in vivo and in vitro. Four groups (n = 12 per group) of anesthetized… Expand