The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion.
The Lambeth Conventions are guidelines intended to be of practical value in the investigation of arrhythmias induced by ischaemia, infarction, and reperfusion and are encouraged to adopt in the hope that this will improve uniformity and interlaboratory comparisons.
The isolated blood and perfusion fluid perfused heart.
- F. J. Sutherland, D. Hearse
- BiologyPharmacological Research
- 1 June 2000
An insight is given into the many factors which must be taken into consideration when first establishing these preparations, the range of indices that can be measured and the potential pitfalls which, with a little care, can be readily avoided.
Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction.
- M. Maxwell, D. Hearse, D. Yellon
- Medicine, BiologyCardiovascular Research
- 1 October 1987
It is concluded that a wide spectrum of collateral flow exists between various mammalian species, a fact that should be taken into account in the study of the pathophysiology and control of regional ischaemia and myocardial infarction.
Reperfusion-induced arrhythmias: mechanisms and prevention.
- A. Manning, D. Hearse
- MedicineJournal of Molecular and Cellular Cardiology
- 1 June 1984
Experimental models for the study of cardiovascular function and disease.
- D. Hearse, F. J. Sutherland
- MedicinePharmacological Research
- 1 June 2000
This article endeavours to identify some of these strengths and weaknesses and reveals the frequently encountered paradox that the greater the amount and reproducibility of data the further removed is the model from clinical reality.
Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.
- P. Garlick, M. Davies, D. Hearse, T. Slater
- BiologyCirculation Research
- 1 November 1987
It is demonstrated that reperfusion after a period of ischemia results in a sudden increase in the production of free radicals in the myocardium, and ESR signals obtained are consistent with the spin-trapping by PBN of either a carbon-centered species or an alkoxyl radical, both of which could be formed by secondary reactions of initially-formed oxygen radicals with membrane lipid components.
Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion.
- P. Eaton, N. Wright, D. Hearse, M. Shattock
- BiologyJournal of Molecular and Cellular Cardiology
- 1 November 2002
Protein S-glutathiolation was attenuated by the antioxidant mercaptopropionylglycine and was shown to occur only during the firstminutes of reperfusion, and GAPDH oxidation is associated with a loss in reduced cysteine status that correlates with the inactivation of this enzyme.
Ischemic contracture of the myocardium: mechanisms and prevention.
- D. Hearse, P. Garlick, S. M. Humphrey
- Biology, MedicineAmerican Journal of Cardiology
- 1 June 1977
Reperfusion of the ischemic myocardium.
- D. Hearse
- MedicineJournal of Molecular and Cellular Cardiology
- 1 August 1977
Reperfusion‐induced Arrhythmias and Oxygen‐derived Free Radicals: Studies with “Anti‐Free Radical” Interventions and a Free Radical‐generating System in the Isolated Perfused Rat Heart
- M. Bernier, D. Hearse, A. Manning
- Biology, MedicineCirculation Research
- 1 March 1986
Evidence is shown that oxygen-derived free radicals play an important role in the genesis of reperfusion-induced arrhythmias, and simultaneous perfusion of the hearts with FeCl3 ± adenosine diphosphate and “anti-free radical” interventions again reduced reperfusions rhythm disturbances.
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