• Publications
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Cardiac ionic currents and acute ischemia: from channels to arrhythmias.
  • E. Carmeliet
  • Medicine, Chemistry
  • Physiological reviews
  • 1 July 1999
The aim of this review is to provide basic information on the electrophysiological changes during acute ischemia and reperfusion from the level of ion channels up to the level of multicellularExpand
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Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.
  • E. Carmeliet
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 August 1992
The delayed K+ current (ik) and its change by dofetilide was studied in single myocytes from the guinea pig and rabbit heart using the two-electrode voltage clamp technique. In rabbit myocytes, ikExpand
  • 321
  • 17
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome
Deletion of amino-acid residues 1505–1507 (KPQ) in the cardiac SCN5A Na+ channel causes autosomal dominant prolongation of the electrocardiographic QT interval (long-QT syndrome type 3 or LQT3).Expand
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Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium.
BACKGROUND The ventricular action potential exhibits regional heterogeneity in configuration and duration (APD). Across the left ventricular (LV) free wall, this is explained by differences inExpand
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T‐type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea‐pig ventricular myocytes
1 We have investigated whether Ca2+ entry through T‐type Ca2+ channels participates in triggering Ca2+ release from the sarcoplasmic reticulum (SR) in single guinea‐pig ventricular myocytesExpand
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Single cardiac Purkinje cells: general electrophysiology and voltage‐clamp analysis of the pace‐maker current.
Single Purkinje cells from dog, sheep and cow hearts were isolated by injecting a Ca‐free collagenase containing Tyrode solution in the space between the connective tissue sheath and the PurkinjeExpand
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Use-dependent block and use-dependent unblock of the delayed rectifier K+ current by almokalant in rabbit ventricular myocytes.
  • E. Carmeliet
  • Chemistry, Medicine
  • Circulation research
  • 1 November 1993
A voltage-clamp analysis of the effect of almokalant on the delayed rectifier K+ current (IK) was made in rabbit ventricular myocytes. The two-suction pipette method was used, and appropriateExpand
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[Ca2+]i transients and [Ca2+]i‐dependent chloride current in single Purkinje cells from rabbit heart.
1. Single Purkinje cells, enzymatically isolated from rabbit ventricle, were studied under whole‐cell voltage clamp and internally perfused with the fluorescent Ca2+ indicator, indo‐1 (100 microM).Expand
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Existence of two transient outward currents in sheep cardiac Purkinje fibers
Voltage clamp analysis of the transient outward (positive dynamic) current was performed in sheep Purkinje fibers at a pulse frequency of 1/min. 4-aminopyridine (4-AP, 1 mM) suppressed most of theExpand
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Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres
An analysis of the slowly inactivating Na current in rabbit cardiac Purkinje fibres was made, using the twomicroelectrode voltage clamp technique. The existence of the slowly inactivating Na currentExpand
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