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Quinolines, antirheumatic drugs

Known as: Quinolines 
National Institutes of Health

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Quinolines

Papers overview

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Highly Cited
2014
Highly Cited
2014
Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we… 
Highly Cited
2011
Highly Cited
2011
Iridium-catalyzed hydrogenation of N-heterocyclic compounds under mild conditions by an outer-sphere pathway.
A new homogeneous iridium catalyst gives hydrogenation of quinolines under unprecedentedly mild conditions-as low as 1 atm of H(2… 
Highly Cited
2006
Highly Cited
2006
Asymmetric hydrogenation of quinolines and isoquinolines activated by chloroformates.
Despite significant progress in the area of asymmetric hydrogenation, the enantioselective hydrogenation of aromatic and… 
Highly Cited
2004
Highly Cited
2004
Entrapment and release of quinoline derivatives using a hydrogel of a low molecular weight gelator.
Highly Cited
2002
Highly Cited
2002
Discovery of novel targets of quinoline drugs in the human purine binding proteome.
The quinolines have been used in the treatment of malaria, arthritis, and lupus for many years, yet the precise mechanism of… 
Highly Cited
2000
Highly Cited
2000
Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots.
The roots of Cryptolepis sanguinolenta have been investigated for their chemical composition since 1931 but so far no studies on… 
Highly Cited
1998
Highly Cited
1998
A Common Mechanism for Blockade of Heme Polymerization by Antimalarial Quinolines*
The antimalarial quinolines are believed to work by blocking the polymerization of toxic heme released during hemoglobin… 
Highly Cited
1996
Highly Cited
1996
In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis
The antileishmanial efficacies of 2-n-propylquinoline, chimanines B and D, 2-n-pentylquinoline, 2-phenylquinoline, 2-(3,4… 
Highly Cited
1995
Highly Cited
1995
Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.
A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination… 
Highly Cited
1988
Highly Cited
1988
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
Multidrug resistance (MDR), typified by resistance to Vinca alkaloids and anthracyclines, is a well characterized experimental… 
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