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Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe
In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the Annonaceae family, particularly Annona muricata, and these plants contain a class of powerful, lipophilic complex I inhibitors, the annonaceous acetogenins, which support the hypothesis that some forms of parkinsonist might be induced by environmental toxins. Expand
Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis.
This study has demonstrated that Pera benensis, a medicinal plant used in folk medicine, is an efficient treatment of cutaneous leishmaniasis. Expand
The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism
This study demonstrates that annonacin promotes dopaminergic neuronal death by impairment of energy production and underlines the need to address its possible role in the etiology of some atypical forms of Parkinsonism in Guadeloupe. Expand
Antiparasitic activities of medicinal plants used in Ivory Coast.
During an ethnopharmacological survey of antiparasitic medicinal plants used in Ivory Coast, 17 plants were identified and collected and antimalarial, leishmanicidal, trypanocidal, antihelminthiasis and antiscabies activities were determined. Expand
Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceousExpand
2-substituted quinoline alkaloids as potential antileishmanial drugs
This study is the first to show the activity of 2-substituted quinoline alkaloids for experimental treatment of New World cutaneous leishmaniasis and further investigations of these compounds might yet prove helpful for the development of new antileishmanial drugs. Expand
Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections.
We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis andExpand
Toxicity of Annonaceae for dopaminergic neurons: Potential role in atypical parkinsonism in Guadeloupe
Alkaloids from A. muricata can modulate the function and the survival of dopaminergic nerve cells in vitro, and it is suggested that repeated consumption could cause the neuronal dysfunction and degeneration underlying the West Indian parkinsonian syndrome. Expand
Antiparasitic activity of some New Caledonian medicinal plants.
Among the selected plants, Scaevola balansae and Premna serratifolia L. were the most active against Leishmania donovani with IC(50) values between 5 and 10microg/ml. Expand
In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis
It is suggested that chimanine B may be chosen as a lead molecule in the development of oral therapy against leishmaniasis. Expand