Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
- R. Desjardins, C. Canfield, J. Haynes, J. Chulay
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 December 1979
A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite Plasmodium falciparum, and results demonstrated that the method is sensitive and precise.
Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.
- S. Looareesuwan, C. Viravan, H. Webster, D. Kyle, D. Hutchinson, C. Canfield
- MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1996
Of the 104 patients with falciparum malaria treated with atovaquone plus proguanil for 3-7 days, 101 were cured and had virtually no adverse side effects, but parasitemia recurred in most patients.
Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.
- C. Canfield, M. Pudney, W. Gutteridge
- MedicineExperimental parasitology
- 1 May 1995
Proguanil emerged as the most promising of the current antimalarials as a partner for atovaquone in a fixed combination, with tetracycline as back-up.
Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.
- S. Looareesuwan, J. Chulay, C. Canfield, D. Hutchinson
- MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1 April 1999
Treatment with atovaquone and proguanil hydrochloride was significantly more effective than mefloquine (Thailand), amodiaquine (Gabon), chloroquine(Peru and the Philippines) or chloroquines plus pyrimethamine/sulfadoxine (Philippines), in clinical trials where the comparator drug was highly effective.
Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrug-resistant Plasmodium falciparum malaria.
- A. Sabchareon, P. Attanath, D. Hutchinson
- Medicine, ChemistryTransactions of the Royal Society of Tropical…
- 1 March 1998
Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia.
- M. Mulenga, T. Sukwa, C. Canfield, D. Hutchinson
- MedicineClinical Therapeutics
- 1 May 1999
MALARONE (cid:121) (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE): A REVIEW OF ITS CLINICAL DEVELOPMENT FOR TREATMENT OF MALARIA
- J. Chulay, C. Canfield
- Medicine
- 1999
Malarone is a safe and effective new agent for treatment of malaria and the most commonly reported adverse events in clinical trials (abdominal pain, anorexia, nausea, vomiting, diarrhea and cough-ing) occurred with similar frequency in patients treated with a comparator drug.
Mefloquine (WR 142,490) in the treatment of human malaria
- C. M. Trenholme, R. Williams, C. Canfield
- MedicineScience
- 21 November 1975
The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria.
Malaria: treatment efficacy of halofantrine (WR 171,669) in initial field trials in Thailand.
- E. Boudreau, L. Pang, C. Canfield
- MedicineBulletin of the World Health Organization
- 1988
Halofantrine appeared to be of comparable efficacy to mefloquine in the treatment of multidrug-resistant P. falciparum malaria.
PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.
- C. Canfield, W. Milhous, D. Jacobus
- Chemistry, BiologyAmerican Journal of Tropical Medicine and Hygiene
- 1 July 1993
Oral administration of this new drug should circumvent the shortcomings and retain the advantages found with both proguanil and WR99210, and represent a new antifolate class of drugs that the authors have named oxyguanils or hydroxylamine-derived biguanides.
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