Pyrin Domain

Known as: PADD Domains, PAAD-DAPIN-PYRIN Domain, DAPIN Domains 
A protein interaction domain of the death domain superfamily. It is characterized by a 6-helix bundle similar to those that occur in DEATH DOMAIN… (More)
National Institutes of Health

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3 relations
Pyrinaspects of radiation effectsphysiological aspects

Papers overview

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Review
2017
Review
2017
The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases
Inflammasomes are multiprotein complexes that critically control different aspects of innate and adaptive immunity. Among them we… (More)
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Highly Cited
2014
Highly Cited
2014
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
Cytosolic inflammasome complexes mediated by a pattern recognition receptor (PRR) defend against pathogen infection by activating… (More)
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Highly Cited
2011
Highly Cited
2011
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury.
The colonic epithelium self-renews every 3 to 5 d, but our understanding of the underlying processes preserving wound healing… (More)
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Highly Cited
2011
Highly Cited
2011
The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance
The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a… (More)
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Highly Cited
2010
Highly Cited
2010
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.
Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the… (More)
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Highly Cited
2009
Highly Cited
2009
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like… (More)
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Highly Cited
2009
Highly Cited
2009
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and… (More)
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Highly Cited
2005
Highly Cited
2005
A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection.
Proinflammatory caspases play an essential role in innate immune responses to infection by regulating the cleavage and activation… (More)
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Highly Cited
2002
Highly Cited
2002
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains.
Large mammalian proteins containing a nucleotide-binding domain (NBD) and C-terminal leucine-rich repeats (LRR) similar in… (More)
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Highly Cited
2001
Highly Cited
2001
The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation
In pro-apoptotic signaling pathways, the interaction between the different initiator units such as the death receptor Fas, the… (More)
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