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Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.
Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional, proinflammatory cytokine that is capable of activating a diverse number of target genes within multiple cell types. Little information isExpand
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Pneumocystis carinii.
  • S. Levine
  • Medicine
  • Clinics in chest medicine
  • 1996
Improved understanding of Pneumocystis carinii, in particular the widespread use of chemoprophylaxis, has resulted in a declining incidence of infection in patients infected with HIV since the lateExpand
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The relationship of psychosocial factors to coronary heart disease in the Framingham study. I. Methods and risk factors.
Questionnaires administered to 1822 members of the Framingham Heart Study from 1965 to 1967 provided measures of personality type, sociocultural mobility, situational stress and somatic strain.Expand
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Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
Soluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa ectodomain of TNFR1 has been recognized as the mechanism by whichExpand
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Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
  • M. Yu, S. Levine
  • Biology, Medicine
  • Cytokine & growth factor reviews
  • 1 April 2011
Double-stranded RNA (dsRNA), the genetic material for many RNA viruses, induces robust host immune responses via pattern recognition receptors, which include Toll-like receptor 3 (TLR3), retinoicExpand
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Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.
We have elicited and characterized the serological specificity of five murine monoclonal antibodies (DU-PAN-1, 2, 3, 4, and 5) to a human pancreatic tumor cell line, HPAF. The antibodies are notExpand
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Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line.
Human airway epithelial cells play an active role in modulating airway inflammation by elaborating a variety of proinflammatory molecules, including cytokines. The purpose of this study was to defineExpand
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Molecular Mechanisms of Soluble Cytokine Receptor Generation*
  • S. Levine
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 23 May 2008
Soluble cytokine receptors play key roles in regulating cytokine-mediated biological events by binding and modulating the activity of target ligands in either an antagonistic or agonistic fashion.Expand
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Maple syrup urine disease: further evidence that newborn screening may fail to identify variant forms.
Newborn screening (NBS) by tandem mass spectrometry (MS/MS) has allowed for early detection and initiation of treatment in many patients with maple syrup urine disease (MSUD) (OMIM 248600), however,Expand
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Airway Inflammation
Dr. James H. Shelhamer (National Institutes of Health [NIH], Bethesda, Maryland): Inflammation of the conducting airways is a feature of lung diseases characterized by airway obstruction andExpand
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