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Proto-Oncogene Proteins p21(ras)

Known as: ras, Proto-Oncogene Protein, c-ras, p21, Proteins c-ras, Proto-Oncogene 
Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric… Expand
National Institutes of Health

Related topics

Related topics

26 relations
Costello syndrome (disorder)GTP BindingGTP Binding DomainGenes, ras
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Narrower (8)

HRAS protein, humanK-Ras4B protein, humanKRAS protein, humanKRAS4B protein, mouse
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Papers overview

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Highly Cited
2004
Highly Cited
2004
Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum.
Development of new drugs is one of the strategies for malaria control. The biosynthesis of several isoprenoids in Plasmodium… Expand
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2003
2003
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Anti-neutrophil cytoplasm autoantibodies (ANCA) are implicated in the pathogenesis of systemic vasculitis. Intact ANCA IgG… Expand
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Highly Cited
2002
Highly Cited
2002
Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Coxsackievirus B3 (CVB3) is the most common human pathogen for viral myocarditis. We have previously shown that the signaling… Expand
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Highly Cited
2001
Highly Cited
2001
Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation.
Furin, a predominant convertase of the cellular constitutive secretory pathway, is known to be involved in the maturation of a… Expand
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2001
2001
Hyperactivation of P21ras and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro
Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type I (NF1), a disease characterized by the formation of… Expand
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Highly Cited
2000
Highly Cited
2000
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the… Expand
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Highly Cited
1999
Highly Cited
1999
Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication.
Recently, we reported on tyrosine phosphorylation of distinct cellular proteins in the course of enterovirus infections (M. Huber… Expand
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Highly Cited
1999
Highly Cited
1999
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
Regulated activation of the highly conserved Ras GTPase is a central event in the stimulation of cell proliferation, motility… Expand
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Highly Cited
1997
Highly Cited
1997
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide… Expand
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Highly Cited
1997
Highly Cited
1997
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction.
We have identified the site of molecular interaction between nitric oxide (NO) and p21(ras) responsible for initiation of signal… Expand
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