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Proto-Oncogene Proteins p21(ras)

Known as: ras, Proto-Oncogene Protein, c-ras, p21, Proteins c-ras, Proto-Oncogene 
Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2015
0102019892015

Related topics

Related topics

24 relations
Costello syndrome (disorder)GTP BindingGTP Binding DomainGenes, ras
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Narrower (3)

c-Ha-ras p21p21 K-Ras Proteinp21 N-Ras Protein

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Proto-Oncogene Proteins p21(ras)
Signal Transduction
physiological aspects
agonists
Guanosine Triphosphate Phosphohydrolases
chemical synthesis

Papers overview

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Highly Cited
2000
Highly Cited
2000
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism.
Recruitment to activated tyrosine kinase growth factor receptors of Grb2 and p21(ras) leads to downstream activation of the… (More)
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Highly Cited
2000
Highly Cited
2000
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress.
Advanced glycation end products (AGEs) exert their cellular effects on cells by interacting with specific cellular receptors, the… (More)
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Highly Cited
1997
Highly Cited
1997
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide… (More)
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Highly Cited
1997
Highly Cited
1997
Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine.
Although hyperhomocysteinemia has been recognized recently as a prevalent risk factor for myocardial infarction and stroke, the… (More)
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Highly Cited
1997
Highly Cited
1997
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction.
We have identified the site of molecular interaction between nitric oxide (NO) and p21(ras) responsible for initiation of signal… (More)
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Highly Cited
1997
Highly Cited
1997
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Adenosine exerts a mitogenic effect on human endothelial cells via stimulation of the A2A-adenosine receptor. This effect can… (More)
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Highly Cited
1996
Highly Cited
1996
Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated…
In cultured rat vascular smooth muscle cells, angiotensin II (Ang II) induced a rapid increase in mitogen-activated protein… (More)
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Highly Cited
1996
Highly Cited
1996
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.
The mitogen-activated protein (MAP) kinase family includes extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase… (More)
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Highly Cited
1996
Highly Cited
1996
Differential activation of mitogen-activated protein kinases by nitric oxide-related species.
Many studies have identified nitric oxide (NO) and related chemical species (NOx) as having critical roles in neurotransmission… (More)
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