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Morphine and Pain-Related Stimuli Enhance Cell Surface Availability of Somatic δ-Opioid Receptors in Rat Dorsal Root Ganglia
TLDR
It is demonstrated that DRG neurons express perikaryal δORs accessible to CSF-circulating ligands and that the density and, hence, presumably also the responsiveness, of these receptors may be modulated by both pain-related stimuli and sustained exposure to μOR agonists. Expand
Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by κ Opioid Activation of p38 Mitogen-Activated Protein Kinase
TLDR
The hypothesis that KOR activation induces spinal astrocyte proliferation, which may contribute to cellular reorganization after sciatic nerve damage, is supported. Expand
The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms.
TLDR
This review summarizes knowledge of the functions and the signaling mechanisms involved in the actions of the AT(2) receptor in neurons and cells of neuronal origin and proposes a role for it in control of neuronal plasticity. Expand
Activation of Spinal μ- and δ-Opioid Receptors Potently Inhibits Substance P Release Induced by Peripheral Noxious Stimuli
TLDR
It is found that both agonists were able to decrease formalin- and capsaicin-induced pain, an effect that was correlated with a reduction in the number of c-fos-positive neurons in the superficial laminae of the lumbar spinal cord. Expand
Essential role of mu opioid receptor in the regulation of delta opioid receptor–mediated antihyperalgesia
TLDR
DOR-mediated antihyperalgesia is dependent on MOR expression but that activation of MOR by endogenous opioids is probably not required, and the regulation of DOR's effects was also independent of beta-endorphin, enkephalins, or dynorphin opioids known to be released during persistent inflammation. Expand
Behavioral, Medical Imaging and Histopathological Features of a New Rat Model of Bone Cancer Pain
TLDR
This model of rat femoral mammary carcinoma MRMT-1 cell implantation demonstrates the importance of simultaneously recording pain and tumor progression and will allow us to better characterize therapeutic strategies in the future. Expand
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain
TLDR
In CFA-treated rats, pharmacological treatment of anxiety-like behaviors induced by chronic inflammatory pain can be objectively evaluated using multiple behavioral tests and could help identify/validate alternative potential targets that influence pain and cognitive dimensions of anxiety. Expand
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents
TLDR
Observations suggest that repeated injections of DOPR agonists induce differential tolerance effects on antihyperalgesic, antinociceptive, and motor incoordination/ataxia-like behaviors related to DopR activation by deltorphin II. Expand
Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin
TLDR
It is found that chronic inflammation produced by injection of complete Freund's adjuvant into the hind paw resulted in a bilateral increase in the binding and internalization of fluorescent deltorphin in neurons of the lumbar spinal cord as did prolonged morphine treatment, demonstrating that in chronic inflammation, the antihyperalgesic effects of deltaOR agonists may be enhanced by morphine pre-treatment. Expand
Spinal μ and δ Opioids Inhibit Both Thermal and Mechanical Pain in Rats
TLDR
The results reveal that the activation of spinal MOPR and DOPR relieves both heat-induced and mechanically induced pain with similar potency and suggest that these receptors are expressed on polymodal, substance P-expressing neurons. Expand
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