Proto-Oncogene Proteins c-ret

Known as: c-ret, Proto-Oncogene Proteins, Proto-Oncogene Proteins, ret, Proto-Oncogene Protein Ret 
Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR ligands. They contain an extracellular… (More)
National Institutes of Health

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In BloodProcess of secretionRET geneagonists
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RET protein, humanRet oncogene protein, Drosophila

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Highly Cited
2012
Highly Cited
2012
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
The identification of the molecular events that drive cancer transformation is essential to the development of targeted agents… (More)
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Review
2002
Review
2002
RET/PTC rearrangement in thyroid tumors.
Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most common genetic alteration identified to date in… (More)
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Highly Cited
2002
Highly Cited
2002
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.
RET/papillary thyroid carcinoma (PTC) oncogenes, generated by recombination of the tyrosine kinase-encoding domain of RET with… (More)
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Review
2001
Review
2001
RET oncogene activation in papillary thyroid carcinoma.
The RET proto-oncogene encodes a cell membrane tyrosine-kinase receptor protein whose ligands belong to the glial cell line… (More)
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Highly Cited
1998
Highly Cited
1998
The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.
Our research goal is to better understand the mechanisms controlling the initiation and progression of thyroid diseases. One such… (More)
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Highly Cited
1997
Highly Cited
1997
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.
In this study, we compare the morphological and genetic characteristics of 38 post-Chernobyl thyroid papillary carcinomas from… (More)
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Highly Cited
1997
Highly Cited
1997
Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the…
Glial cell line-derived neurotrophic factor (GDNF), the most potent trophic factor yet described for both dopaminergic neurons of… (More)
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Highly Cited
1997
Highly Cited
1997
High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
A high frequency (about 60%) of ret rearrangements in papillary thyroid carcinomas of children exposed to radioactive fallout in… (More)
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Highly Cited
1996
Highly Cited
1996
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.
Gene rearrangements activating the RET proto-oncogene are frequently associated with human thyroid carcinomas belonging to the… (More)
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Highly Cited
1994
Highly Cited
1994
Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.
The RET proto-oncogene encodes a transmembrane receptor of the tyrosine kinase family and has frequently been found activated in… (More)
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