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Complement factor H polymorphism in age-related macular degeneration.
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204Expand
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Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
Antibody-secreting hybrid cells have been derived from a fusion between mouse myeloma cells and spleen cells from a mouse immunized with membrane from human tonsil lymphocyte preparations. HybridsExpand
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HTRA1 promoter polymorphism in wet age-related macular degeneration.
Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular).Expand
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A marker of early amacrine cell development in rat retina.
A monoclonal antibody, HPC-1, labels only amacrine and displaced amacrine cells in adult rat retina. Reactivity with displaced amacrine cells was demonstrated by double-label immunofluorescence withExpand
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Thy-1 antigen: A ganglion cell specific marker in rodent retina
A monoclonal antibody, 2G12 , has been produced against a rat cerebral cortex glycoprotein fraction. It interacts with Thy-1 based on both the tissue distribution of its reactivity and the blockingExpand
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Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential
Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigmentExpand
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Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.
The mitochondrial uncoupling protein (UCP2) is expressed in selected regions of the brain. Here we demonstrate that up-regulation of UCP2 is part of a neuroprotective set of responses to variousExpand
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The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina.
Recent evidence implicates homeodomain-containing proteins in the specification of cell fates in the central nervous system. Here we report that in the embryonic mouse eye Otx2, a paired homeodomainExpand
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PEDF: a multifaceted neurotrophic factor
Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamateExpand
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Monoclonal antibodies that recognize discrete forms of tubulin.
Anti-tubulin antibodies secreted by plasmacytoma NSI-spleen cell hybrids were detected by an indirect binding assay. Different antibodies bound to different combinations of the tubulins as resolvedExpand
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