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Complement factor H polymorphism in age-related macular degeneration.
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204… Expand
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
Antibody-secreting hybrid cells have been derived from a fusion between mouse myeloma cells and spleen cells from a mouse immunized with membrane from human tonsil lymphocyte preparations. Hybrids… Expand
HTRA1 promoter polymorphism in wet age-related macular degeneration.
Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular).… Expand
A marker of early amacrine cell development in rat retina.
A monoclonal antibody, HPC-1, labels only amacrine and displaced amacrine cells in adult rat retina. Reactivity with displaced amacrine cells was demonstrated by double-label immunofluorescence with… Expand
Thy-1 antigen: A ganglion cell specific marker in rodent retina
A monoclonal antibody, 2G12 , has been produced against a rat cerebral cortex glycoprotein fraction. It interacts with Thy-1 based on both the tissue distribution of its reactivity and the blocking… Expand
Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential
Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment… Expand
Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.
The mitochondrial uncoupling protein (UCP2) is expressed in selected regions of the brain. Here we demonstrate that up-regulation of UCP2 is part of a neuroprotective set of responses to various… Expand
The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina.
- D. Baas, K. M. Bumsted, J. Martínez, F. Vaccarino, K. Wikler, C. Barnstable
- Biology, Medicine
- Brain research. Molecular brain research
- 31 May 2000
Recent evidence implicates homeodomain-containing proteins in the specification of cell fates in the central nervous system. Here we report that in the embryonic mouse eye Otx2, a paired homeodomain… Expand
PEDF: a multifaceted neurotrophic factor
Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate… Expand
Monoclonal antibodies that recognize discrete forms of tubulin.
- I. Gozes, C. Barnstable
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1982
Anti-tubulin antibodies secreted by plasmacytoma NSI-spleen cell hybrids were detected by an indirect binding assay. Different antibodies bound to different combinations of the tubulins as resolved… Expand