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Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is characterized by a… Expand
Epigenetic inactivation of CHFR in human tumors
- M. Toyota, Y. Sasaki, +11 authors T. Tokino
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 16 June 2003
Cell-cycle checkpoints controlling the orderly progression through mitosis are frequently disrupted in human cancers. One such checkpoint, entry into metaphase, is regulated by the CHFR gene encoding… Expand
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.
The ret proto-oncogene expresses four major mRNA species of different lengths in human malignant cell lines and rat tissues. We isolated ret proto-oncogene cDNA clones from a cDNA library of a human… Expand
Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.
The incidences of microsatellite instability (MSI) and underlying DNA mismatch repair (MMR) defects in pancreatic carcinogenesis have not been well established. We analyzed 100 sporadic and 3… Expand
Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers
BACKGROUND/AIM Matrilysin is one of the matrix metalloproteinases that has a critical role in tumour invasion, and is often expressed in gastrointestinal cancers. The aim of this study was to examine… Expand
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
- H. Yamamoto, F. Itoh, +6 authors K. Imai
- Journal of clinical oncology : official journal…
- 15 February 2001
PURPOSE A disruption in the balance between the matrix metalloproteinases (MMPs) and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs), has been implicated in the progression… Expand
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer
Activation of Wnt signaling has been implicated in gastric tumorigenesis, although mutations in APC (adenomatous polyposis coli), CTNNB1 (β-catenin) and AXIN are seen much less frequently in gastric… Expand
Clinicopathologic and prognostic significance of matrilysin expression at the invasive front in human colorectal cancers
Matrix metalloproteinases (MMPs) have been implicated in tumor progression. Matrilysin, one of the matrix metalloproteinases, is frequently overexpressed in gastrointestinal cancers. The aim of our… Expand
PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer
- Y. Watanabe, M. Toyota, +12 authors T. Tokino
- Biology, Medicine
- Clinical Cancer Research
- 15 August 2007
Purpose: PR (PRDI-BF1 and RIZ) domain proteins (PRDM) are a subfamily of the kruppel-like zinc finger gene products that play key roles during cell differentiation and malignant transformation. The… Expand
Protein profiles of peripheral blood mononuclear cells are useful for differential diagnosis of ulcerative colitis and Crohn’s disease
BackgroundEffective biomarkers for discrimination between ulcerative colitis (UC) and Crohn’s disease (CD) have not been established yet. In this study, we analyzed protein profiles of peripheral… Expand