Protein Tyrosine Phosphatase, Receptor-Type, N

Known as: Protein Tyrosine Phosphatase, Receptor Type N, PTPase IA2, Insulinoma Associated Protein 2 
 
National Institutes of Health

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PTPRN gene

Papers overview

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2006
2006
Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies.
CONTEXT Type 1A diabetes is characterized by a long prodromal phase during which autoantibodies to islet antigens are present… (More)
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Highly Cited
2001
Highly Cited
2001
Diabetic autoimmune markers in children and adolescents with type 2 diabetes.
BACKGROUND There is an increase in the incidence of type 2 diabetes in children and adolescents. Absence of known diabetes… (More)
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Highly Cited
2001
Highly Cited
2001
Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
Islet cell autoantigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of… (More)
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2000
2000
The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.
Islet cell autoantigen (ICA) 512 of type I diabetes is a receptor tyrosine phosphatase-like protein associated with the secretory… (More)
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Highly Cited
2000
Highly Cited
2000
βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System
We report the identification of betaIV spectrin, a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase… (More)
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1999
1999
Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.
The autoantigen of type I diabetes ICA512 is a receptor tyrosine phosphatase-like protein enriched in the secretory granule… (More)
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1996
1996
Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.
Antibodies to islet cell proteins detected as 37,000 and 40,000 M(r), tryptic fragments (37- and 40-kDa antigens) are strongly… (More)
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Highly Cited
1995
Highly Cited
1995
Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies.
The majority of patients with insulin-dependent diabetes (IDDM) have Abs to 40- and/or 37-kDa tryptic fragments (37/40K-Abs… (More)
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1995
1995
Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase.
The presence of serum islet cell cytoplasmic antibodies (ICAs) is a standard autoimmune marker for insulin-dependent diabetes… (More)
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1995
1995
ICA512 autoantibody radioassay.
As part of a general program of screening islet expression libraries we have identified a clone from a lambda gt11 human islet… (More)
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