The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.

@article{Ort2000TheRT,
  title={The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.},
  author={Tatiana Ort and Elena Maksimova and Ronald A Dirkx and Amy M. Kachinsky and Stanny C Berghs and Stanley C. Froehner and Michele Solimena},
  journal={European journal of cell biology},
  year={2000},
  volume={79 9},
  pages={621-30}
}
Islet cell autoantigen (ICA) 512 of type I diabetes is a receptor tyrosine phosphatase-like protein associated with the secretory granules of neurons and endocrine cells including insulin-secreting beta-cells of the pancreas. Here we show that in a yeast two-hybrid assay its cytoplasmic domain binds beta2-syntrophin, a modular adapter which in muscle cells… CONTINUE READING