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Protein Patched Homolog 1, human

Known as: Protein Patched Homolog 1, Patched, PTCH 
Protein patched homolog 1 (1447 aa, ~161 kDa) is encoded by the human PTCH1 gene. This protein is involved in the modulation of hedgehog protein… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
ABSTRACT Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular… Expand
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Highly Cited
2000
Highly Cited
2000
Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the… Expand
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Highly Cited
1999
Highly Cited
1999
Cerebellar granule cells are the most abundant type of neuron in the brain, but the molecular mechanisms that control their… Expand
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Highly Cited
1998
Highly Cited
1998
Basal-cell carcinomas (BCCs) are the commonest human cancer. Insight into their genesis came from identification of mutations in… Expand
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Highly Cited
1998
Highly Cited
1998
Lateral assemblies of glycolipids and cholesterol, “rafts,” have been implicated to play a role in cellular processes like… Expand
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Highly Cited
1997
Highly Cited
1997
The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell… Expand
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Highly Cited
1996
Highly Cited
1996
Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of skeletal elements, yet little is known… Expand
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Highly Cited
1996
Highly Cited
1996
The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers… Expand
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Highly Cited
1996
Highly Cited
1996
The nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell… Expand
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Highly Cited
1996
Highly Cited
1996
The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds… Expand
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