Protein Patched Homolog 1, human

Known as: Protein Patched Homolog 1, Patched, PTCH 
Protein patched homolog 1 (1447 aa, ~161 kDa) is encoded by the human PTCH1 gene. This protein is involved in the modulation of hedgehog protein… (More)
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that trigger ligand-independent activity of the… (More)
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Highly Cited
2000
Highly Cited
2000
Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the… (More)
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Highly Cited
1998
Highly Cited
1998
Lateral assemblies of glycolipids and cholesterol, "rafts," have been implicated to play a role in cellular processes like… (More)
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Highly Cited
1997
Highly Cited
1997
Inactivating mutations in the PTCH gene, a human homologue of the Drosophila segment polarity gene patched, have been identified… (More)
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Highly Cited
1996
Highly Cited
1996
The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers… (More)
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Highly Cited
1996
Highly Cited
1996
The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts… (More)
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Highly Cited
1996
Highly Cited
1996
Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein… (More)
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Highly Cited
1996
Highly Cited
1996
The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds… (More)
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Highly Cited
1996
Highly Cited
1996
THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the… (More)
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Highly Cited
1996
Highly Cited
1996
Hedgehog genes have been implicated in inductive signaling during development in a variety of organisms. A key element of the… (More)
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