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Protein Patched Homolog 1, human

Known as: Protein Patched Homolog 1, Patched, PTCH 
Protein patched homolog 1 (1447 aa, ~161 kDa) is encoded by the human PTCH1 gene. This protein is involved in the modulation of hedgehog protein… 
National Institutes of Health

Related topics

Related topics

17 relations
Axon GuidanceBiologic DevelopmentCellular MembraneEmbryonic Development

Broader (1)

Patched Receptors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Evidence for Antibody-Mediated Injury as a Major Determinant of Late Kidney Allograft Failure
Background. Late graft failure (LGF) is believed to be the consequence of immunologic and nonimmunologic insults leading to… 
Highly Cited
2000
Highly Cited
2000
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.
Basal cell carcinoma is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the… 
Review
2000
Review
2000
The sonic hedgehog-patched-gli pathway in human development and disease.
Highly Cited
1998
Highly Cited
1998
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.
Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by… 
Highly Cited
1998
Highly Cited
1998
FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development.
The development of calvarial bones is tightly co-ordinated with the growth of the brain and needs harmonious interactions between… 
Highly Cited
1997
Highly Cited
1997
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a… 
Highly Cited
1997
Highly Cited
1997
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
Branching morphogenesis of the embryonic lung requires interactions between the epithelium and the mesenchyme. Previously, we… 
Highly Cited
1997
Highly Cited
1997
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.
Inactivating mutations in the PTCH gene, a human homologue of the Drosophila segment polarity gene patched, have been identified… 
Highly Cited
1996
Highly Cited
1996
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling… 
Highly Cited
1987
Highly Cited
1987
Sickle-cell trait as a risk factor for sudden death in physical training.
Case reports of sudden death during exertion have not established an association between the sickle-cell trait (hemoglobin AS… 
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