I. Thesleff

Publications334
h-index103
Citations32,811
Highly Influential Citations1,659
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Reiterative signaling and patterning during mammalian tooth morphogenesis
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Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
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Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.
TLDR
It is shown that coordinated epithelial-mesenchymal interactions are essential during the initial stages of palate development and require an Fgf-Shh signaling network and that cell proliferation is decreased not only in the palatal epithelium but also in the mesenchyme of Fgfr2b-/- mice.
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Epithelial-mesenchymal signalling regulating tooth morphogenesis
TLDR
Interactions between the ectoderm and underlying mesenchyme constitute a central mechanism regulating the morphogenesis of teeth in vertebrate embryos.
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Localization of Putative Stem Cells in Dental Epithelium and Their Association with Notch and Fgf Signaling
TLDR
A model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression is presented and has a central role in coupling the mitogenesis and fate decision of stem cells.
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Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene.
TLDR
It is suggested that the enamel knot may control tooth morphogenesis by concurrently stimulating cusp growth (via FGF-4 synthesis) and by directing folding of cusp slopes (by not proliferating itself).
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Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.
TLDR
This work uses positional cloning to identify the causative mutation in a Finnish family in which severe permanent tooth agenesis (oligodontia) and predisposition to cancer are caused by a nonsense mutation, Arg656Stop, in the Wnt-signaling regulator AXIN2, and introduces a new gene for hereditary colorectal cancer.
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FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development.
TLDR
It is suggested that conserved signalling pathways regulate tissue interactions during suture morphogenesis and intramembranous bone formation of the calvaria and that morphogenesis of mouse sagittal suture is controlled by different molecular mechanisms during the embryonic and postnatal stages.
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Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
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FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis
TLDR
Genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear is provided, suggesting that in contrast to mesenchymal–epithelial-based FGF10 signaling demonstrated for other organs, the innerEar seems to depend on paracrine signals that operate within the epithelium.
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