I. Thesleff

Publications332
h-index101
Citations31,008
Highly Influential Citations1,580
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Reiterative signaling and patterning during mammalian tooth morphogenesis
Mammalian dentition consists of teeth that develop as discrete organs. From anterior to posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth types.… Expand
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Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development
Growth factor-mediated signaling has been implicated in the regulation of epithelial-mesenchymal interactions during organogenesis. Bone morphogenetic protein 4 (BMP-4), a member of the transforming… Expand
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Localization of Putative Stem Cells in Dental Epithelium and Their Association with Notch and Fgf Signaling
The continuously growing mouse incisor is an excellent model to analyze the mechanisms for stem cell lineage. We designed an organ culture method for the apical end of the incisor and analyzed the… Expand
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Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.
Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process. Using Fgf10-/-, FGF… Expand
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Epithelial-mesenchymal signalling regulating tooth morphogenesis
  • I. Thesleff
  • Biology, Medicine
  • Journal of Cell Science
  • 1 May 2003
Teeth develop as ectodermal appendages in vertebrate embryos, and their early development resembles morphologically as well as molecularly other organs such as hairs and glands. Interactions between… Expand
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Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene.
The main morphological features of the mammalian tooth crown are cusps, but the developmental mechanisms that cause the formation of cusps are unknown. Tooth cusp formation commences at cap-stage… Expand
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Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
A novel murine plasma membrane protein has been identified in subpopulations of macrophages. It has an intracellular N-terminal domain, a transmembrane domain, and an extracellular region with a… Expand
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FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development.
The development of calvarial bones is tightly co-ordinated with the growth of the brain and needs harmonious interactions between different tissues within the calvarial sutures. Premature fusion of… Expand
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The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot.
The enamel knot, a transient epithelial structure, appears at the onset of mammalian tooth shape development. Until now, the morphological, cellular and molecular events leading to the formation and… Expand
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Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.
Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs. Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used positional cloning to identify… Expand
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