Protein Argonaute-2

Known as: PPD, PAZ Piwi Domain Protein, eIF2C 2 
Protein argonaute-2 (859 aa, ~97 kDa) is encoded by the human EIF2C2 gene. This protein plays a role in RNA catabolism.
National Institutes of Health

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Topic mentions per year

1971-2018
0204019712018

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Highly Cited
2008
Highly Cited
2008
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from… (More)
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Highly Cited
2007
Highly Cited
2007
MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha… (More)
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA… (More)
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Highly Cited
2005
Highly Cited
2005
Argonaute proteins play important yet distinct roles in RNA silencing. Human Argonaute2 (hAgo2) was shown to be responsible for… (More)
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Highly Cited
2004
Highly Cited
2004
In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA… (More)
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Highly Cited
2004
Highly Cited
2004
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The… (More)
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Highly Cited
2004
Highly Cited
2004
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two… (More)
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Highly Cited
2002
Highly Cited
2002
Fragile X syndrome is a common form of inherited mental retardation caused by the loss of FMR1 expression. The FMR1 gene encodes… (More)
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Highly Cited
2002
Highly Cited
2002
Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of RNA interference (RNAi). Here, we… (More)
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Highly Cited
2001
Highly Cited
2001
Double-stranded RNA induces potent and specific gene silencing through a process referred to as RNA interference (RNAi) or… (More)
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