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Protease Nexins

Known as: Nexin, Protease, Nexin, Protease Associated, Protease Nexin 
Extracellular protease inhibitors that are secreted from FIBROBLASTS. They form a covalent complex with SERINE PROTEASES and can mediate their… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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1999
1999
Protease nexin I expression is up‐regulated in human skeletal muscle by injury‐related factors
Protease nexin I is a 43–50 kDa glycoprotein capable of inhibiting a number of serine proteases. In cultured differentiated human… 
1998
1998
Developmental regulation of the serpin, protease nexin I, localization during activity‐dependent polyneuronal synapse elimination in mouse skeletal muscle
During vertebrate neuromuscular development, all muscle fibers are transiently innervated by more than one neuron. Among the… 
Highly Cited
1995
Highly Cited
1995
A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.
Protease nexin I (PNI) is a member of the family of serine protease inhibitors (serpins) that have been shown to promote neurite… 
1995
1995
Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1.
The mechanism for the inhibition of thrombin by the serpins antithrombin and protease nexin 1 has been investigated using several… 
Highly Cited
1992
Highly Cited
1992
Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytes
Highly Cited
1989
Highly Cited
1989
Protease nexin I immunostaining in alzheimer's disease
Immunohistochemical experiments showed that a small subset of neuritic plaques in brains affected by Alzheimer's disease stain… 
Highly Cited
1986
Highly Cited
1986
Purification and characterization of a novel inhibitor of urokinase from human urine. Quantitation and preliminary characterization in plasma.
Highly Cited
1986
Highly Cited
1986
Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I.
Human fibrosarcoma (HT-1080) cells, in contrast to normal fibroblasts, rapidly hydrolyze the glycoprotein, collagen, and elastin… 
Highly Cited
1984
Highly Cited
1984
Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.
Recently we presented evidence that normal human foreskin fibroblasts (HF cells) limit the activity of secreted urokinase by… 
Highly Cited
1983
Highly Cited
1983
Protease nexins: Cell‐secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases
The protease nexins (PN‐I, Mr ∼︁38,000; PN‐II, Mr ∼︁95,000; and PN‐III, Mr ∼︁31,000) are recently described cell‐secreted… 
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