Propofol

Known as: 2,6-Diisopropylphenol, Phenol, 2,6-bis(1-methylethyl)-, Propofolum 
A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Unconsciousness is a fundamental component of general anesthesia (GA), but anesthesiologists have no reliable ways to be certain… (More)
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Highly Cited
2012
Highly Cited
2012
CONTEXT Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine… (More)
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Highly Cited
2011
Highly Cited
2011
STUDY OBJECTIVES The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic… (More)
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Review
2005
Review
2005
Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use. Because of the occurrence… (More)
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Highly Cited
2005
Highly Cited
2005
Propofol (2,6-diisopropylphenol) is a hypnotic intravenous agent with in vivo antioxidant properties. This study was undertaken… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The authors studied the influence of age on the pharmacodynamics of propofol, including characterization of the… (More)
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Highly Cited
1999
Highly Cited
1999
In the present study, we used positron emission tomography to investigate changes in regional cerebral blood flow (rCBF) during a… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Unresolved issues with propofol include whether the pharmacokinetics are linear with dose, are influenced by method of… (More)
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Highly Cited
1991
Highly Cited
1991
A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing… (More)
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