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Propofol

Known as: 2,6-Diisopropylphenol, Phenol, 2,6-bis(1-methylethyl)-, Propofolum 
A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Significance Anesthesiologists reversibly manipulate the brain function of nearly 60,000 patients each day, but brain-state… 
Highly Cited
2012
Highly Cited
2012
CONTEXT Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND The authors studied the influence of age on the pharmacodynamics of propofol, including characterization of the… 
Highly Cited
1998
Highly Cited
1998
Background Unresolved issues with propofol include whether the pharmacokinetics are linear with dose, are influenced by method of… 
Highly Cited
1997
Highly Cited
1997
Background: The bispectral index (BIS), a value derived from the electroencephalograph (EEG), has been proposed as a measure of… 
Highly Cited
1997
Highly Cited
1997
Background: The bispectral index (BIS), a parameter derived from the electroencephalograph (EEG), has been shown to correlate… 
Review
1995
Review
1995
BACKGROUND Between June 1990 and February 1993, the Centers for Disease Control and Prevention conducted investigations at seven… 
Review
1992
Review
1992
OBJECTIVE--To examine the possible contribution of sedation with propofol in the deaths of children who were intubated and… 
Highly Cited
1991
Highly Cited
1991
A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing… 
Highly Cited
1988
Highly Cited
1988
The haemodynamic effects of propofol, given as a single dose of 2 mg kg-1 immediately followed by a continuous infusion of 6 mg…