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SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist
TLDR
The results suggest that SB 242084 is the first reported selective potent and brain penetrant 5- HT2C receptor antagonist and has anxiolytic-like activity, but does not possess either proconvulsant or hyperphagic properties which are characteristic of mutant mice lacking the 5-HT2C receptors. Expand
In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties
TLDR
The results suggest that SB 206553 is a potent mixed 5‐HT2C/5-HT2B receptor antagonist with selectivity over the 5‐ HT2A and all other sites studied and possesses anxiolytic‐like properties. Expand
5-HT2 receptor subtypes: a family re-united?
TLDR
The pharmacology of both officially recognized and atypical 5- HT2 receptor subtypes is examined and a number of novel selective agents are highlighted, some of which may prove useful for 5-HT2 receptor classification and clarify the mechanistic basis for current and future therapeutic strategies which target this receptor family. Expand
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Nature Med. 8, 825–830 (2002). Bharat Lagu was omitted from the list of authors. The correct list is below. B. Borowsky, M.M. Durkin, K. Ogozalek, M.R. Marzabadi, J. DeLeon, B. Lagu, R. Heurich, H.Expand
Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS
TLDR
The overall distribution of 5-HT2C-like immunoreactivity complements previous findings with conventional radioligands and agrees well with reported levels of5- HT2C receptor mRNA. Expand
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
TLDR
SNAP-7941, a selective, high-affinity MCH1 receptor (MCH1-R) antagonist, inhibited food intake stimulated by central administration of MCH, reduced consumption of palatable food, and, after chronic administration to rats with diet-induced obesity, resulted in a marked, sustained decrease in body weight. Expand
Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.
TLDR
Results indicate that Gal(3)-selective antagonists produce anxiolytic- and antidepressant-like effects, possibly by attenuating the inhibitory influence of galanin on 5-HT transmission at the level of the dorsal raphe nucleus. Expand
Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system
TLDR
This study identifies receptor expression in longitudinal and circular smooth muscle in the rat stomach fundus and in neurons in discrete nuclei in the cerebellum, lateral septum, dorsal hypothalamus and medial amygdala and the potential function of this receptor in the CNS is discussed. Expand
Attenuation of haloperidol‐induced catalepsy by a 5‐HT2C receptor antagonist
TLDR
The data suggest a role for 5‐HT2C receptors in the anticataleptic action of SB‐228357, and suggest that atypical neuroleptics produce fewer extrapyramidal side‐effects (EPS) than typical neurolePTics. Expand
Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety
TLDR
In conclusion, BW 723C86 exerted an appreciable anxiolytic‐like profile in a rat social interaction test, but had a weaker effect in the Geller‐Siefter and was ineffective in the elevated x‐maze test used. Expand
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