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Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most… Expand In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising… Expand The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… Expand Aging is a general process of functional decline which involves in particular a decline of cognitive abilities. However, the… Expand Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through… Expand Steroidogenesis begins with the metabolism of cholesterol to pregnenolone by the inner mitochondrial membrane cytochrome P450… Expand screen of the microscope. Between 150 to 300 nerve fibers were analyzed per cross section. 13. C. F. Eldridge, M. Bartlett, R. P… Expand Delivery of cholesterol to inner mitochondrial membranes is rate-limiting for steroidogenesis in the zona fasciculata of adrenal… Expand Oligodendrocyte mitochondria from 21-day-old Sprague-Dawley male rats were incubated with 100 nM [3H]cholesterol. It yielded [3H… Expand Ketoconazole has recently been shown to interfere with steroidogenesis in patients and rat in vitro systems. In this study we… Expand