Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery
- A. Ströhle, E. Romeo, R. Rupprecht
- Medicine, BiologyBiological Psychiatry
- 1 February 1999
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology
- R. Rupprecht, F. Michele, F. Holsboer
- Biology, PsychologyBrain Research Reviews
- 1 November 2001
Stimulation of Brain Pregnenolone Synthesis by Mitochondrial Diazepam Binding Inhibitor Receptor Ligands In Vivo
- A. Korneyev, B. Pan, A. Polo, E. Romeo, A. Guidotti, E. Costa
- Biology, MedicineJournal of Neurochemistry
- 1 October 1993
Treatment with the MDR ligands 4‐CD and FGIN‐1–27 increased the pregnenolone content in the brain but failed to change the plasma or peripheral tissue content of this steroid, suggesting that glial cell MDRs play a role in neurosteroid biosynthesis in vivo.
Plasma Concentrations of Neuroactive Steroids before and after Repetitive Transcranial Magnetic Stimulation (rTMS) in Major Depression
- F. Padberg, F. Michele, R. Rupprecht
- Psychology, BiologyNeuropsychopharmacology
- 1 November 2002
Allopregnanolone affects sleep in a benzodiazepine-like fashion.
- M. Lancel, J. Faulhaber, R. Rupprecht
- BiologyJournal of Pharmacology and Experimental…
- 1 September 1997
The data indicate that the steroid allopregnanolone has benzodiazepine-like effects on sleep, very similar to those elicited by larger doses of progesterone, which produce comparable brain levels of allopremolone.
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
- J. Auta, E. Romeo, A. Kozikowski, D. Ma, E. Costa, A. Guidotti
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 May 1993
Alpidem, like clonazepam, zolpidem and diazepam, but not THDOC or FGIN-1-27, delay the onset of bicuculline-induced convulsions.
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
- E. Romeo, J. Auta, A. Guidotti
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 September 1992
The 2 aryl-3-indoleacetamides (FGIN-1) are a new class of compounds that potently (nM) and selectively bind to glial mitochondrial diazepam binding inhibitor (DBI) receptors (MDR), previously called…
The pharmacology of neurosteroidogenesis
- E. Costa, J. Auta, A. Guidotti, A. Korneyev, E. Romeo
- Biology, ChemistryJournal of Steroid Biochemistry and Molecular…
- 1 June 1994
Marked decrease of plasma neuroactive steroids during alcohol withdrawal.
- E. Romeo, A. Brancati, A. Pasini
- Medicine, PsychologyClinical neuropharmacology
- 1 August 1996
The results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.
Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
- E. Romeo, S. Cavallaro, A. Guidotti
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 1993
Both drugs failed to increase adrenal steroidogenesis in sham-operated rats and both drugs reduced fear of novelty in the elevated plus maze test.
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